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职业迁徙
个人简介
Current Research Interest
Current research in my laboratory centers on characterization of a novel protein in centriole biogenesis and primary cilium formation with the aim to elucidate the relationship of the protein with other centriole- and cilium-associated proteins, which to this end may reveal the novel molecular mechanisms underlying centriole and ciliary biogenesis and functions.
The fundamental question behind our work is how the centrosome and primary cilium control cell function and influence development, and how defects in these structures cause a remarkable range of human disease. The centrosome is the microtubule-organising centre (MTOC) of the cell, and so it regulates cell motility, adhesion and polarity in interphase, and facilitates the organization of the spindle poles during mitosis. Abnormalities in the spindle-pole-organization function occur in many cancers because extra and often irregular centrosomes can give rise to aberrant cell division. In addition, the core centrosomal components, the centrioles, have another distinct function as basal bodies that seed the growth of cilia. Cells in G0 and G1 usually contain one centrosome consisting of two centrioles, termed the mother centriole and the daughter centriole. The mother or older centriole is characterized by the presence of appendages that are formed during cell cycle progression. Moreover, when cells escape the cell cycle the mother centriole eventually give rise to the basal body that outgrows a primary cilium. Disturbances of primary cilia underly a lot of human diseases, e.g. kidney diseases, left-right axes formation and hydrocephalus.
Current research in my laboratory centers on characterization of a novel protein in centriole biogenesis and primary cilium formation with the aim to elucidate the relationship of the protein with other centriole- and cilium-associated proteins, which to this end may reveal the novel molecular mechanisms underlying centriole and ciliary biogenesis and functions.
The fundamental question behind our work is how the centrosome and primary cilium control cell function and influence development, and how defects in these structures cause a remarkable range of human disease. The centrosome is the microtubule-organising centre (MTOC) of the cell, and so it regulates cell motility, adhesion and polarity in interphase, and facilitates the organization of the spindle poles during mitosis. Abnormalities in the spindle-pole-organization function occur in many cancers because extra and often irregular centrosomes can give rise to aberrant cell division. In addition, the core centrosomal components, the centrioles, have another distinct function as basal bodies that seed the growth of cilia. Cells in G0 and G1 usually contain one centrosome consisting of two centrioles, termed the mother centriole and the daughter centriole. The mother or older centriole is characterized by the presence of appendages that are formed during cell cycle progression. Moreover, when cells escape the cell cycle the mother centriole eventually give rise to the basal body that outgrows a primary cilium. Disturbances of primary cilia underly a lot of human diseases, e.g. kidney diseases, left-right axes formation and hydrocephalus.
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