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During the last decade a unique mechanism of negative regulation of immune responses and inflammation by a dedicated population of so-called regulatory T (Treg) cells has become the focus of intensive investigation. Expression of the transcription factor Foxp3, a hallmark of Treg cells, is necessary for the establishment and maintenance of a distinct transcriptional program that determines metabolic, signaling, and effector features (e.g., suppressive function), distinguishing these cells from other T cell lineages. The long-term goals of our research are to identify the molecular determinants of differentiation and function of Treg cells and to ultimately gain insight into the complex biology of these cells, including the maintenance of immunological tolerance to "self" and the regulation of immune responses to pathogens, commensals, and tumors.
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论文共 91 篇作者统计合作学者相似作者
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The Journal of experimental medicineno. 1 (2024)
引用1浏览0WOS引用
1
0
SCIENCE IMMUNOLOGYno. 89 (2023)
JOURNAL OF EXPERIMENTAL MEDICINEno. 1 (2023)
Chia-Hao Lin,Cheng-Jang Wu,Sunglim Cho,Rasika Patkar, William J. Huth,Ling-Li Lin,Mei-Chi Chen,Elisabeth Israelsson,Joanne Betts, Magdalena Niedzielska,Shefali A. Patel, Han G. Duong,
biorxiv(2023)
NATURE IMMUNOLOGY (2023)
引用0浏览0引用
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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The Journal of experimental medicineno. 10 (2023)
biorxiv(2022)
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