基本信息
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职业迁徙
个人简介
Areas of Expertise
1) heat shock protein 90 2) molecular chaperones and cancer 3) molecularly targeted drug development 4) stress response pathways in cancer 5) targeting proteostasis in cancer 6) regulation of cell metabolism by kinase and chaperone networks
An early proponent of translational research, Dr. Neckers pioneered development of oligonucleotide-based therapeutic strategies. Recently, Dr. Neckers has been investigating the role of chaperone proteins in signal transduction. His identification of benzoquinone ansamycins as specific antagonists of the chaperone HSP90 uncovered the importance of this protein for the growth and survival of cancer cells and led directly to the first phase I clinical trial of an HSP90 antagonist as an anticancer agent. Dr. Neckers continues to examine the pivotal role of Hsp90 in cancer cell survival, and participates in the ongoing translational development of Hsp90 inhibitors as novel anti-cancer agents. Dr. Neckers holds several patents and has been the recipient of several NIH Merit and NIH Inventor's Awards.
研究兴趣
论文共 140 篇作者统计合作学者相似作者
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Grace B. McKay-Corkum, Victor J. Collins,Choh Yeung,Takeshi Ito,Sameer H. Issaq,David Holland, Ksenia Vulikh,Yiping Zhang, Unsun Lee,Haiyan Lei,Arnulfo Mendoza,Jack F. Shern,
CLINICAL CANCER RESEARCHno. 21 (2023): 4479-4491
Mayumi Kawabe,Maja Mandic,Jennifer L. Taylor, Cecilia A. Vasquez,Amy K. Wesa,Leonard M. Neckers,Walter J. Storkus
crossref(2023)
Mayumi Kawabe,Maja Mandic,Jennifer L. Taylor, Cecilia A. Vasquez,Amy K. Wesa,Leonard M. Neckers,Walter J. Storkus
crossref(2023)
Frank J Echtenkamp,Ryo Ishida,Genesis M Rivera-Marquez, Marisa Maisiak,Oleta T Johnson,Jonathan H Shrimp, Arnav Sinha,Stephen John Ralph, Ian Nisbet,Murali Krishna Cherukuri,Jason E Gestwicki,Leonard M Neckers
PNAS nexusno. 4 (2023): pgad115-pgad115
crossref(2023)
Michael A. Moses,Yeong Sang Kim,Genesis M. Rivera-Marquez,Nobu Oshima,Matthew J. Watson,Kristin E. Beebe, Catherine Wells,Sunmin Lee,Abbey D. Zuehlke,Hao Shao, William E. Bingman,Vineet Kumar,
crossref(2023)
Nature reviews. Molecular cell biologyno. 11 (2023): 797-815
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