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A major challenge in systems biology is how to extract meaningful biological insights from large heterogeneous data sets that probe different aspects of gene function. Our laboratory uses high-throughput functional genomics and computational approaches to study the cell biology, post-translational regulation, and evolution of molecular mechanisms during early embryonic development in the simple animal model C. elegans and related nematodes. For example, since most diseases are multigenic in origin, we are generating genome-wide genetic interaction maps for genes with essential roles in the early embryo that will help us understand how these interactions affect embryogenesis. By integrating diverse functional genomics data, we seek to gain a better understanding of how different groups of genes work together to coordinate cellular and developmental processes.
研究兴趣
论文共 108 篇作者统计合作学者相似作者
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Megan N. Guerin, TreVaughn Ellis, Mark J. Ware, Alexandra Manning, Ariana Coley, Ali Amini,George Chung,Kristin C. Gunsalus,John R. Bracht
biorxiv(2023)
Gennaro Esposito,Yamanappa Hunashal, Mathias Percipalle,Federico Fogolari, Tomas Venit, Ainars Leonchiks,Kristin C. Gunsalus,Fabio Piano,Piergiorgio Percipalle
biorxiv(2023)
biorxiv(2022)
crossref(2021)
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