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个人简介
Dr. Burns is a physician-scientist and practicing hematopathologist. Her research laboratory studies roles transposable elements play in human disease. Her lab was one of the first to develop a targeted method for amplifying mobile DNA insertion sites in the human genome, and show that these are a significant source of structural variation (Cell, 2010). Her group continues to characterize these understudied sequences in genomes and to describe the expression and genetic stability of interspersed repeats in normal and malignant tissues.
The lab has described the overexpression of Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) in a wide array of human cancers (American Journal of Pathology, 2014). They have mapped somatically-acquired LINE-1 insertion sites incurred during the evolution of pancreatic ductal adenocarcinomas (Nature Medicine, 2015) and ovarian cancers (Proceedings of the National Academy of Sciences, 2017). The lab has ongoing projects focused on the functional consequences of inherited mobile element insertions (Proceedings of the National Academy of Sciences, 2017) and LINE-1 expression in cancers (Nature Structural and Molecular Biology, 2020).
Dr. Burns has authored reviews on human transposons (Cell, 2012), their activities in cancer (Nature Reviews Cancer, 2017), and their impact on gene expression (Nature Reviews Genetics, 2019). She has organized several national and international meetings in the field, and has been continuously funded by the National Institutes of Health for her research.
The lab has described the overexpression of Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) in a wide array of human cancers (American Journal of Pathology, 2014). They have mapped somatically-acquired LINE-1 insertion sites incurred during the evolution of pancreatic ductal adenocarcinomas (Nature Medicine, 2015) and ovarian cancers (Proceedings of the National Academy of Sciences, 2017). The lab has ongoing projects focused on the functional consequences of inherited mobile element insertions (Proceedings of the National Academy of Sciences, 2017) and LINE-1 expression in cancers (Nature Structural and Molecular Biology, 2020).
Dr. Burns has authored reviews on human transposons (Cell, 2012), their activities in cancer (Nature Reviews Cancer, 2017), and their impact on gene expression (Nature Reviews Genetics, 2019). She has organized several national and international meetings in the field, and has been continuously funded by the National Institutes of Health for her research.
研究兴趣
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BIOLOGY OF REPRODUCTION (2024)
Jordina Rincon-Torroella,James Feghali,Albert Antar, Tej D Azad, Antony Rosen,Roy C Ziegelstein, Paul B Rothman,Kathleen H Burns,Jessica L Bienstock, Andrea L Cox, Chetan Bettegowda
Pamela R. de Santiago,Sho Sato, Yelena Zhuravlev, Hannah S. Rendulich, Marty S. Taylor,Connie Wu,Meaghan C. Dougher,Lauren Schwartz, David R. Walt,Kathleen H. Burns,Ronny Drapkin
Eric T. Baldwin, Trevor van Eeuwen,David Hoyos, Arthur Zalevsky,Egor P. Tchesnokov, Roberto Sánchez, Bryant D. Miller,Luciano H. Di Stefano,Francesc Xavier Ruiz, Matthew Hancock, Esin Işik,Carlos Mendez-Dorantes,
Natureno. 7997 (2024): 194-206
Ali AlJabban, Henry Paik,Jon C. Aster,Nancy Berliner, Jennifer Brouillard,Jennifer R. Brown,Kathleen H. Burns,Jorge J. Castillo, James Card,Paola Dal Cin,Daniel J. DeAngelo,David M. Dorfman,
Cancer Researchno. 6_Supplement (2024): 404-404
CLINICAL CHEMISTRYno. 1 (2024): 1-3
Mobile DNAno. 1 (2023): 19-19
Kevin C. L. Cheng,Jennifer M. Frost,Francisco J. Sánchez-Luque,Marta García-Canãdas,Darren Taylor,Wan R. Yang, Branavy Irayanar, Swetha Sampath,Hemalvi Patani,Karl Agger,Kristian Helin,Gabriella Ficz,
Epigenetics & chromatinno. 1 (2023): 1-16
openalex(2023)
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