基本信息
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个人简介
Awards
2014 Peter Yates Lecture, University of Toronto
2005 Prize for excellent basic research at Saxony-Anhalt
2001 Dorothea-Erxleben-Prize (best doctoral thesis)
Major Research Interests
The central research topic of our department is the analysis of molecular reaction mechanisms of enzymes as nature's chemical catalysts. In this context, we study enzymes with vitamin-derived cofactors, with metal ions, and Schiff base-forming enzymes. A particular focus is laid on the structural and kinetic characterization of enzymatic reaction intermediates by high-resolution X-ray crystallography, steady-state and transient kinetic methods, NMR spectroscopy and theoretical studies. Knowledge about the reaction mechanism is exploited to redesign enzymes for biocatalytic applications and for drug design.
2014 Peter Yates Lecture, University of Toronto
2005 Prize for excellent basic research at Saxony-Anhalt
2001 Dorothea-Erxleben-Prize (best doctoral thesis)
Major Research Interests
The central research topic of our department is the analysis of molecular reaction mechanisms of enzymes as nature's chemical catalysts. In this context, we study enzymes with vitamin-derived cofactors, with metal ions, and Schiff base-forming enzymes. A particular focus is laid on the structural and kinetic characterization of enzymatic reaction intermediates by high-resolution X-ray crystallography, steady-state and transient kinetic methods, NMR spectroscopy and theoretical studies. Knowledge about the reaction mechanism is exploited to redesign enzymes for biocatalytic applications and for drug design.
研究兴趣
论文共 116 篇作者统计合作学者相似作者
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Lisa-Marie Funk,Gereon Poschmann,Fabian Rabe von Pappenheim,Ashwin Chari,Kim M. Stegmann,Antje Dickmanns, Marie Wensien, Nora Eulig, Elham Paknia, Gabi Heyne, Elke Penka,Arwen R. Pearson,
Nature Communicationsno. 1 (2024): 1-18
Ashish Tamhankar, Marie Wensien, Sergio A V Jannuzzi,Sayanti Chatterjee,Benedikt Lassalle-Kaiser,Kai Tittmann,Serena DeBeer
The journal of physical chemistry lettersno. 16 (2024): 4263-4267
Angewandte Chemie (International ed. in English)no. 36 (2023)
ACS CATALYSISno. 1 (2023): 355-365
The journal of physical chemistry. Bno. 44 (2023)
Research Square (Research Square) (2023)
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Sören Rindfleisch,Matthias Krull,Jon Uranga, Tobias Schmidt,Fabian Rabe von Pappenheim,Laura Liliana Kirck,Angeliki Balouri,Thomas Schneider,Ashwin Chari,Ronald Kluger,Gleb Bourenkov,Ulf Diederichsen,
Lisa-Marie Funk,Gereon Poschmann,Ashwin Chari,Fabian Rabe von Pappenheim, Kim-Maren Stegmann,Antje Dickmanns, Nora Eulig,Marie Wensien, Elham Paknia, Gabi Heyne, Elke Penka,Arwen R. Pearson,
biorxiv(2022)
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