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The primary focus of the laboratory is to explore how peptides from marine sources may be developed into therapeutically active drugs. Peptides are responsible for diverse physiological functions, and the actions of antimicrobial peptides are highly significant for the survival of nearly all species. Over the past several years, our work exploring the potential clinical applications of piscidin and epinecidin-1 has led them to become prominent antimicrobial peptides. We also seek to design and explore how to best modify antimicrobial peptides from marine organisms in order to decrease the peptide toxicity and increase the half-life in serum. In one project, the novel anticancer peptides we have derived from antimicrobial peptides are conjugated to homing peptides in an effort to develop cancer therapeutics with high specificity and low side effects. The dedication of the researchers in the laboratory is evident from their high-impact publications, patents, and products.
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论文共 155 篇作者统计合作学者相似作者
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Po-Hsien Hsu,Prakash Kishore Hazam, Yi-Ping Huang, Jih-Chao Yeh,Yun-Ru Chen, Chao-Chin Li,Chi-Fon Chang, Je-Wen Liou,Jyh-Yih Chen
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2024): 116083-116083
Fish & Shellfish Immunology (2023): 108880-108880
European Journal of Medicinal Chemistry (2023)
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European journal of medicinal chemistry (2023): 115131-115131
Microbiology spectrumno. 2 (2023)
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Sanjay Prasad Selvaraj,Jyh-Yih Chen
European journal of medicinal chemistry (2023): 115680-115680
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