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Dr. Josie Ursini-Siegel is an Assistant Professor at the Lady Davis Institute for Medical Research, a member of the Jewish General Hospital/Segal Cancer Center and the Department of Oncology at McGill University. Cancer cells induce the recruitment of, and are interdispersed within, a tumor stroma that includes fibroblasts, endothelial cells, immune cells and extracellular matrix components. Indeed, an activated stroma promotes breast cancer progression and facilitates metastatic spread, the most devastating aspect of this disease. Dr. Ursini-Siegel is interested in understanding the mechanism by which the ShcA adaptor protein regulates signal transduction pathways in breast cancer cells to facilitate communication with the local microenvironment and promote the establishment of a pro-tumorigenic reactive stroma. To achieve this, she utilizes a genetic approach to alter ShcA signalling or expression in well characterized transgenic breast cancer mouse models.
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论文共 69 篇作者统计合作学者相似作者
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HaEun Kim, Benjamin Lebeau,David Papadopoli,Predrag Jovanovic, Mariana Russo,Daina Avizonis,Masahiro Morita,Farzaneh Afzali,Josie Ursini-Siegel,Lynne -Marie Postovit,Michael Witcher,Ivan Topisirovic
ISCIENCEno. 3 (2024): 109188-109188
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 4 (2024): e2318093121-e2318093121
Kyle Lewis,Rachel La Selva, Elias Maldonado, Matthew G. Annis,Ouafa Najyb, Eduardo Cepeda Canedo,Stephanie Totten, Steven Hebert,Valerie Sabourin, Caitlynn Mirabelli, Emma Ciccolini,Camille Lehuede,
Cancer Researchno. 7_Supplement (2023): 1279-1279
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Emma Ciccolini, Valerie Sabourin, David Patten, Young K. Im, Steven Hebert,William J. Muller,Claudia Kleinman,Julie St-Pierre,Josie Ursini-Siegel
CANCER RESEARCHno. 7 (2023)
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Caitlynn Nicole Mirabelli,Rachel La Selva,Matthew Annis,Ouafa Najyb,Steven Hebert,Claudia Kleinman,Julie St-Pierre,Peter Siegel,Josie Ursini-Siegel
CANCER RESEARCHno. 7 (2023)
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Tim Kong,Ryuhjin Ahn,Kangning Yang,Xianbing Zhu,Zheng Fu,Geneviève Morin, Rachel Bramley, Nikki C. Cliffe,Yibo Xue,Hellen Kuasne, Qinghao Li, Sungmi Jung,
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Tim Kong,Ryuhjin Ahn,Kangning Yang,Xianbing Zhu,Zheng Fu,Geneviève Morin, Rachel Bramley, Nikki C. Cliffe,Yibo Xue,Hellen Kuasne, Qinghao Li, Sungmi Jung,
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