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Dr. Halperin has authored books and journal articles in the field of cardiology and maintained a stream of clinical investigations, beginning with studies of cardiovascular hemodynamics that contributed to the development of angiotensin converting enzyme inhibition for patients with heart failure and studies of regional circulation related to the management of patients with Raynaud's Disease, mitral valve disease and intermittent claudication. He was the principal cardiologist responsible for the design and execution of the Stroke Prevention in Atrial Fibrillation (SPAF) clinical trials, sponsored by the National Institutes of Health. Clinical evidence from these trials helped to develop antithrombotic strategies to prevent stroke among the millions of people with atrial fibrillation. He served as Co-Chairman of the Executive Steering Committee of the international SPORTIF trials, which evaluated the first oral direct thrombin inhibitor for prevention of stroke in patients with atrial fibrillation and as a member of the Executive Steering Committee of the ROCKET-AF trial which evaluated the first oral factor Xa inhibitor for this indication. He is currently engaged in trials developing improved therapeutic approaches for prevention of morbid events in an array of cardiovascular disease states, including atrial fibrillation.
研究兴趣
论文共 415 篇作者统计合作学者相似作者
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JACC-CLINICAL ELECTROPHYSIOLOGYno. 2 (2024): 270-283
JACC. Clinical electrophysiologyno. 8 Pt 3 (2023): 1804-1815
Frans J. Beerkens, Amanda Owens, Nikola Kocovic, Aleesha Shaik, Aviv Alter, Amit Blumfield, Brandon Needelman, Brian Hsia, Vinh-Tung Nguyen, Beth G. Raucher, David C. Thomas,Jonathan L. Halperin
JOURNAL OF GENERAL INTERNAL MEDICINE (2023): S139-S140
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Mayo Clinic proceedingsno. 6 (2023): 892-902
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Journal of the American College of Cardiologyno. 8 (2023): 2947-2947
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Journal of the American College of Cardiologyno. 18 (2023): 1774-1776
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