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He has also been researching how the oocyte-cumulus cell complex matures. One facet of this research has involved determining how the oocyte-derived members of the TGFb superfamily, particularly growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15), regulate follicular function and ovulation. Eppig and his laboratory found that, to compensate for their metabolic deficiencies, mammalian oocytes promote metabolic pathways in cumulus cells. In analyzing the transcriptomes of cumulus cells from wild-type, Bmp15-deficient, and Bmp15-/- Gdf9+/- double mutant mice, he found the following:
Most of the genes encoding enzymes for sterol biosynthesis are down-regulated in the mutant cumulus cells and in wild-type cells whose oocytes are removed;
Little newly synthesized cholesterol is present in these cumulus cells;
Many genes that encode enzymes in the cholesterol biosynthetic pathway are robustly expressed in wild-type cumulus cells but hardly expressed in wild-type oocytes;
Newly synthesized cholesterol is significantly higher in cumulus-enclosed oocytes than in denuded oocytes.
Most of the genes encoding enzymes for sterol biosynthesis are down-regulated in the mutant cumulus cells and in wild-type cells whose oocytes are removed;
Little newly synthesized cholesterol is present in these cumulus cells;
Many genes that encode enzymes in the cholesterol biosynthetic pathway are robustly expressed in wild-type cumulus cells but hardly expressed in wild-type oocytes;
Newly synthesized cholesterol is significantly higher in cumulus-enclosed oocytes than in denuded oocytes.
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Proceedings of the National Academy of Sciences of the United States of Americano. 23 (2018): E5326-E5333
Development (Cambridge, England)no. 9 (2017): 1648-1660
Biology of reproductionno. 6 (2014): 142-142
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