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Pathogenesis of neurodegeneration and neuroprotective genes in the retina: The retina consists of neurons which convert light energy into neuronal signals. The normal function of these photoreceptor cells is essential for the vision. Photoreceptor degeneration has been found in many blinding diseases. Using gene knockout animal models and molecular biology approaches such as microarray, proteomics, yeast-two-hybrid system and gene delivery, we are identifying genes responsible for the photoreceptor degeneration and the neuroprotective genes. We are also studying the roles of these genes in the retinal degeneration and exploring their potential applications in the treatment of retinal degeneration.
Pathological angiogenesis, inflammation and vascular leakage in diabetes: Pathological angiogenesis in the retina (neovascularization), inflammation and vascular leakage (hyper-permeability) are common features of diabetic complications and many other diseases such as age-related macular degeneration, cancer, infections and glaucoma. Currently, there is no satisfactory treatment to block the neovascularization and vascular leakage, as their pathogenesis is uncertain. Recently, we have identified several peptide angiogenic inhibitors endogenously expressed in ocular tissues and found that decreased levels of these inhibitors are responsible for the neovascularization and vascular leakage. Using genetic engineering methods, we have expressed these inhibitors and showed that these recombinant peptides can stop neovascularization. They also protect blood-retinal barrier and reduce vascular leakage. We are using molecular biology, biochemistry methods and animal models to study the molecular mechanisms underlying the vascular activities of these peptides. The goal of this research is to develop a new, non-invasive therapy using these natural peptides to block neovascularization and vascular leakage in cancer and diabetes.
Pathogenesis of neurodegeneration and neuroprotective genes in the retina: The retina consists of neurons which convert light energy into neuronal signals. The normal function of these photoreceptor cells is essential for the vision. Photoreceptor degeneration has been found in many blinding diseases. Using gene knockout animal models and molecular biology approaches such as microarray, proteomics, yeast-two-hybrid system and gene delivery, we are identifying genes responsible for the photoreceptor degeneration and the neuroprotective genes. We are also studying the roles of these genes in the retinal degeneration and exploring their potential applications in the treatment of retinal degeneration.
Pathological angiogenesis, inflammation and vascular leakage in diabetes: Pathological angiogenesis in the retina (neovascularization), inflammation and vascular leakage (hyper-permeability) are common features of diabetic complications and many other diseases such as age-related macular degeneration, cancer, infections and glaucoma. Currently, there is no satisfactory treatment to block the neovascularization and vascular leakage, as their pathogenesis is uncertain. Recently, we have identified several peptide angiogenic inhibitors endogenously expressed in ocular tissues and found that decreased levels of these inhibitors are responsible for the neovascularization and vascular leakage. Using genetic engineering methods, we have expressed these inhibitors and showed that these recombinant peptides can stop neovascularization. They also protect blood-retinal barrier and reduce vascular leakage. We are using molecular biology, biochemistry methods and animal models to study the molecular mechanisms underlying the vascular activities of these peptides. The goal of this research is to develop a new, non-invasive therapy using these natural peptides to block neovascularization and vascular leakage in cancer and diabetes.
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Experimental eye research (2024): 109790-109790
Frontiers of Medicinepp.1-27, (2024)
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2024): 123675-123675
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Experimental eye research (2023): 109717-109717
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