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The long term goal of my research program is to understand protein folding and misfolding and what factors influence these conformational changes. Nanopore analysis is an electrophoretic technique which can interrogate a single protein molecule as it interacts with a pore embedded in a membrane. The electronic signal is exquisitely sensitive to the conformation of the molecule and thus can provide structural information which would be difficult to obtain by conventional methods.
Our work with misfolding proteins is leading to a better understanding of the biochemistry and pathology of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Overall, this program will help to understand why proteins misfold and what might be done to prevent this. In the long term, this knowledge may lead to the development of drugs which could be used to treat neurodegenerative and other protein misfolding diseases.
Our work with misfolding proteins is leading to a better understanding of the biochemistry and pathology of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Overall, this program will help to understand why proteins misfold and what might be done to prevent this. In the long term, this knowledge may lead to the development of drugs which could be used to treat neurodegenerative and other protein misfolding diseases.
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Omozojie P Aigbogun,Chukwunonso K Nwabufo,Madeline N Owens,Kevin Allen,Jeremy S. Lee, Christopher P. Phenix,Ed S. Krol
Xenobioticano. 8 (2022): 916-927
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