Jeffrey Aubé
Distinguished Professor
Division of Chemical Biology and Medicinal Chemistry
Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill;Department of Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill;Department of Medicinal Chemistry, University of Kansas
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个人简介
The Aubé laboratory pursues an agenda that mixes innovation in basic chemistry (methodology, total synthesis, and physical organic chemistry) with a commitment to chemical biology and drug discovery.
Our interests in organic chemistry encompass organic synthesis methodology with a dash of natural product total synthesis, especially focusing on alkaloids. One of our signature accomplishments was the discovery of the intramolecular Schmidt reaction of alkyl azides, which has proved of enduring practical utility and evolving theoretical interest. We have devised variations of the process, including intermolecular versions of simple alkyl, “in situ tethering” of hydroxyalkyl azides, an asymmetric version, and domino variations.
In addition to our program in azide chemistry, we have maintained a sustained interest in other aspects of heterocyclic synthesis, with a strong emphasis on stereochemistry and mechanistic detail. Some highlights include an in-depth stereochemical analysis of stereochemistry of the oxaziridine to lactam rearrangement reaction, and study of single-electron transfer reactions of oxaziridines to generate nitrogen radicals. We seek to uncover new principles of physical organic chemistry through the in-depth study of our reactions.
研究兴趣
论文共 583 篇作者统计合作学者相似作者
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Amrita Singh,Samantha Ottavi,Inna Krieger, Kyle Planck,Andrew Perkowski,Takushi Kaneko, Andrew M Davis, Christine Suh, David Zhang, Laurent Goullieux, Alexander Alex, Christine Roubert,
Cancer Researchno. 5_Supplement (2023): P1-13
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JOURNAL OF MEDICINAL CHEMISTRYno. 7 (2023): 867-867
ImmunoHorizonsno. 1 (2023): 116-124
Lanjing Wei,Qi Zhang,Cuncong Zhong,Lily He,Yuxia Zhang, Ahlam M Armaly,Jeffrey Aubé,Danny R Welch,Liang Xu,Xiaoqing Wu
Molecular oncologyno. 10 (2023): 1962-1980
Abid Khan, James M. Metts, Lucas C. Collins,C. Allie Mills,Kelin Li, Amanda L. Brademeyer,Brittany M. Bowman,M. Ben Major,Jeffrey Aubé,Laura E. Herring,Ian J. Davis,Brian D. Strahl
bioRxiv : the preprint server for biology (2023)
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