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Inhibitors of immune checkpoints (ICP) have revolutionised cancer treatment, leading to durable treatment responses in a proportion of patients suffering from previously incurable cancers. The efficacy of this class of drugs is dependent on their ability to trigger the patient’s cytolytic CD8+ T cells targeting tumour cells. However, the broad immune stimulatory capacity of ICP-blockade is associated with a high rate of immune related (irAE). The unpredictability of both efficacy and AEs in response to these agents is a growing concern. There are limited data relating to this heterogeneity of response and the development of irAE following administration of these agents. I will use the following approaches to define the mechanisms leading to the development of irAE.
1.Assessment of rare-patients with monogenic immune dysregulation leading to similar phenotypes as irAE to define candidate genes and pathways.
2.A unique and novel murine system that clonally tracks, self-antigen responsive cells that could cause irAE, in which we can disrupt prioritised pathways identified from our above screening.
1.Assessment of rare-patients with monogenic immune dysregulation leading to similar phenotypes as irAE to define candidate genes and pathways.
2.A unique and novel murine system that clonally tracks, self-antigen responsive cells that could cause irAE, in which we can disrupt prioritised pathways identified from our above screening.
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论文共 86 篇作者统计合作学者相似作者
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Thomas E. Mulroney,Tuija Pöyry,Juan Carlos Yam-Puc, Maria Rust,Robert F. Harvey,Lajos Kalmar, Emily Horner,Lucy Booth,Alexander P. Ferreira,Mark Stoneley,Ritwick Sawarkar, Alexander J. Mentzer,
Natureno. 7993 (2024): 189-194
Hannah K Jackson,Heather M Long,Juan Carlos Yam-Puc, Roberta Palmulli,Tracey A Haigh,Pehuén Pereyra Gerber,Jin S Lee,Nicholas J Matheson, Lesley Young, John Trowsdale, Mathew Lo,Graham S Taylor,
Journal of extracellular vesiclesno. 2 (2024): e12412-e12412
Rebecca H. Boston, Rui Guan,Lajos Kalmar,Sina Beier,Emily C. Horner,Nonantzin Beristain-Covarrubias,Juan Carlos Yam-Puc,Pehuen Pereyra Gerber, Luisa Faria, Anna Kuroshchenkova, Anna E. Lindell,Sonja Blasche,
LIFE SCIENCE ALLIANCEno. 4 (2024)
Thomas E. Mulroney,Tuija Poyry,Juan Carlos Yam-Puc, Maria Rust, Robert F. Harvey,Lajos Kalmar, Emily Horner,Lucy Booth, Alexander P. Ferreira,Mark Stoneley,Ritwick Sawarkar,Alexander J. Mentzer,
NATUREno. 7993 (2024)
Munetomo Takahashi, Ty So,Kate Williamson,Zhaleh Hosseini,Katarzyna Kania, Michelle Ruhle,Tiffeney Mann, Martijn J. Schujis,Paul Coupland,Dean Naisbitt,Timotheus Y.F. Halim,Paul A. Lyons,
biorxiv(2023)
Adriana S. Albuquerque,Jesmeen Maimaris, Alexander J McKenna,Jonathan Lambourne,Fernando Moreira,Sarita Workman,Karyn Mégy,Ilenia Simeoni,Hana Lango Allen, Zoe Adhya,Hana Alachkar,Ariharan Anantharachagan,
Clinical and Experimental Immunologyno. 2 (2023): 166-169
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Juan Carlos Yam-Puc,Zhaleh Hosseini,Emily C. Horner,Pehuén Pereyra Gerber,Nonantzin Beristain-Covarrubias,Robert Hughes,Aleksei Lulla,Maria Rust,Rebecca Boston, Magda Ali,Katrin Fischer, Edward Simmons-Rosello,
Rebecca Boston, Rui Guan, Susanne Baier,Lajos Kalmár,Emily C. Horner,Nonantzin Beristain‐Covarrubias,Juan Carlos Yam‐Puc,Pehuén Pereyra Gerber, Lucas Silva de Faria, Anna Kuroshchenkova,Anna E. Lindell,Sonja Blasche,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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