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The name Horst Kessler is most closely associated with “conformational analysis of peptides, in particular cyclical peptides”. In his work, Horst Kessler linked design to synthetic works, spectroscopic examination and molecular dynamics computations. These methods are now recognized as key processes for the development of new active substances. The question of directed influence of pharmacologically active conformation through ring formation led Horst Kessler to the field of cancer research. Some of the results of his basic research found their way into practice, such as the development of medicines to treat brain tumors or other cancers, the improvement of hip implants and early discovery and characterization of cancer metastases through molecular imaging. Horst Kessler contributed important methodological developments on nuclear magnetic resonance spectroscopy (NMR). In the last two decades, Horst Kessler applied these methods to proteins as well: for example, tumor suppressor protein p53 and its interaction partners as well as various heat shock proteins. His elucidation of terminal domains of spider silk protein, which explains the creation of extremely stable filament spun from the storage form, attracted great interest. He has received international recognition for his scientific and academic wor
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Papers共 656 篇Author StatisticsCo-AuthorSimilar Experts
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Stefano Cinti,Stefano Tomassi,Chiara Ciardiello, Rossella Migliorino,Marinella Pirozzi,Alessandra Leone,Elena Di Gennaro,Virginia Campani,Giuseppe De Rosa,Vincenzo Maria D’Amore,Salvatore Di Maro,Greta Donati,Sima Singh,Ada Raucci,Francesco Saverio Di Leva,Horst Kessler,Alfredo Budillon,Luciana Marinelli
Communications chemistryno. 1 (2024)
Mélissa Messé, Chloé Bernhard,Sophie Foppolo,Lionel Thomas,Patrice Marchand,Christel Herold-Mende,Ahmed Idbaih,Horst Kessler,Nelly Etienne-Selloum, Charles Ochoa, Uttam K. Tambar, Mohamed Elati, Patrice Laquerriere,Natacha Entz-Werle,Sophie Martin, Damien Reita,Monique Dontenwill
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseasepp.167471, (2024)
Journal of molecular and cellular cardiology pluspp.100069-100069, (2024)
Angewandte Chemie (International ed. in English)no. 52 (2023): e202316747-e202316747
Journal of chemical information and modelingno. 20 (2023): 6302-6315
ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 52 (2023)
JOURNAL OF BIOLOGICAL CHEMISTRYno. 9 (2023)
The Journal of biological chemistryno. 9 (2023): 105119-105119
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#Papers: 658
#Citation: 40570
H-Index: 101
G-Index: 182
Sociability: 8
Diversity: 0
Activity: 1
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