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Professor Gray's interdisciplinary research program addresses a wide range of fundamental problems in inorganic chemistry, biochemistry, and biophysics. Electron-transfer (ET) chemistry is a unifying theme for much of this research.
Great progress has been made in understanding how covalent bridges mediate long-range ET reactions. Questions remain, however, regarding the contributions of solvents to long-range interactions between electron donors and acceptors. Gray's research has shown that electron tunneling in aqueous glasses is much less efficient than tunneling across saturated covalent bridges. Investigations of ET reactions between excited metal complexes and electron acceptors in rigid protic and aprotic media are probing the factors that control distant couplings through solvents.
Over the past twenty years the Gray group has been measuring the kinetics of long-range ET reactions in metalloproteins labeled with inorganic redox reagents. Current research is aimed at understanding how intermediate protein radicals accelerate long-range ET. New techniques have been developed for measuring ET rates in crystals of Ru-, Os-, and Re-modified azurins, as well as crystals of Fe(III)-cytochrome c doped with Zn(II)-cytochrome c. This method of integrating photosensitizers into protein crystals has provided a powerful new tool for studying biochemical reaction dynamics.
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CHEMISTRY-A EUROPEAN JOURNALno. 3 (2024)
Accounts of chemical researchno. 14 (2023): 1978-1989
The Journal of Physical Chemistry Bno. 1 (2023): 96-108
FEBS Lettersno. 1 (2023): 59-64
Journal of Inorganic Biochemistry (2022): 111886
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