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职业迁徙
个人简介
Description of Research Expertise
The Wu lab is interested in understanding how epigenetic processes in multicellular organisms regulate gene expression to establish diverse cell types and to respond to changing environmental signals or metabolic states. We combine experimental approaches (biochemical, molecular, genetic, and genomic assays) with bioinformatics to study cell-type specification and maturation from mammalian stem cells (e.g. cardiovascular and neural lineages). We also start to study molecular mechanisms regulating the interaction between environment and epigenome and how extrinsic environmental signals regulate developmental processes or human pathologies through modifying epigenetic marks in the genome. Our long-term goal is to quantitatively analyze and engineer cell-type or environmental context specific epigenomes. Ultimately, we hope to use knowledge gained from epigenome analysis and engineering to inform therapeutic approaches to treat relevant human diseases.
The Wu lab is interested in understanding how epigenetic processes in multicellular organisms regulate gene expression to establish diverse cell types and to respond to changing environmental signals or metabolic states. We combine experimental approaches (biochemical, molecular, genetic, and genomic assays) with bioinformatics to study cell-type specification and maturation from mammalian stem cells (e.g. cardiovascular and neural lineages). We also start to study molecular mechanisms regulating the interaction between environment and epigenome and how extrinsic environmental signals regulate developmental processes or human pathologies through modifying epigenetic marks in the genome. Our long-term goal is to quantitatively analyze and engineer cell-type or environmental context specific epigenomes. Ultimately, we hope to use knowledge gained from epigenome analysis and engineering to inform therapeutic approaches to treat relevant human diseases.
研究兴趣
论文共 61 篇作者统计合作学者相似作者
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Hong Xu,Qi Qiu,Peng Hu, Kevt’her Hoxha, Elliot Jang, Mia O’Reilly, Christopher Kim,Zhuohao He,Nicholas Marotta,Lakshmi Changolkar,Bin Zhang,Hao Wu,
Emily R Feierman, Sean Louzon,Nicholas A Prescott, Tracy Biaco, Qingzeng Gao,Qi Qiu,Kyuhyun Choi,Katherine C Palozola, Anna J Voss, Shreya Mehta, Camille Quaye, Katherine Lynch,
bioRxiv : the preprint server for biology (2024)
Thomas Malachowski,Keerthivasan Raanin Chandradoss, Ravi Boya,Linda Zhou, Ashley L. Luppino, Chuanbin Su,Kenneth Pham,Spencer A. Haws,Ji Hun Kim, Han-Seul Ryu,Chunmin Ge,Jennifer M. Luppino,
bioRxiv : the preprint server for biology (2023)
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biorxiv(2023)
Nature Chemical Biologyno. 8 (2023): 1004-1012
Angewandte Chemie (International ed. in English)no. 32 (2023)
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