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My lab is primarily interested in understanding how meiotic recombination is regulated at the genomic level in higher eukaryotes. While significant progress has been made in understanding many of the molecular components of the recombination process in lower eukaryotes like the yeast S. cerevisiae, far less is known about similar functions in complex multi-cellular organisms. Because of the complexity of higher eukaryotic genomes, the high level of gene duplication and divergence, the presence of DNA modification and the organization of multiple chromosomal domains into heterochromatin the molecules that govern meiotic recombination in these organisms are likely to be novel and of significant biological interest. Additionally, their identification may have practical benefits, contributing to our understanding of human disease genes and providing useful tools for agricultural bioengineering.
A second research area in the lab is investigating the role of centromere DNA in chromosome biology. Centromeres are the chromosomal domains that direct segregation during cell division by mediating a number of critical functions including: attachment of the chromosomes to the spindle microtubules, nucleation of kinetochore proteins, and maintenance of sister chromatid cohesion. Arabidopsis centromeres are some of the best characterized among higher eukaryotes. Currently the efforts in the lab are focused on obtaining a complete definition of the DNA within the genetically defined centromeres of Arabidopsis.
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Frontiers in plant science (2023): 1294591
Proceedings of the National Academy of Sciences of the United States of Americano. 47 (2021)
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