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个人简介
He working on elucidating the mechanism of action of anti-neoplastic drugs under the supervision of Prof. Giulio Superti-Furga at CeMM. He specialized in proteomics as well as chemical genetic approaches to identifying drug resistance mechanisms and on mechanistically elucidating synergistic drug combinations. He continued his training in chemical biology. There, he innovated a generalizable pharmacological solution to in vivo target protein degradation and applied this strategy to the study of leukemic gene regulation. His lab develops and applies methods for target protein degradation with the ultimate goal of understanding and disrupting oncogenic transcriptional circuits. To that end, the Winter laboratory combines phenotypic drug screens, chemical genetics and drug-target identification approaches with holistic measurements of global gene activity and genome structure. The ultimate goal of the research conducted in the Winter laboratory is to connect basic research in gene regulation and the ubiquitin-proteasome system with functional genomics and chemical probe development to develop novel and personalized therapeutic paradigms.
研究兴趣
论文共 91 篇作者统计合作学者相似作者
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Oliver Hsia, Matthias Hinterndorfer,Angus D. Cowan,Kentaro Iso, Tasuku Ishida,Ramasubramanian Sundaramoorthy, Mark A. Nakasone, Hana Imrichova, Caroline Schätz,Andrea Rukavina,Koraljka Husnjak,Martin Wegner,
Natureno. 8002 (2024): 204-211
Nature Chemical Biologyno. 1 (2024): 13-14
Vojtech Dvorak,Andrea Casiraghi,Claire Colas,Anna Koren,Tatjana Tomek, Fabian Offensperger,Andrea Rukavina,Gary Tin,Elisa Hahn, Sarah Dobner,Fabian Frommelt,Andras Boeszoermenyi,
CELL CHEMICAL BIOLOGYno. 8 (2023): 953-964.e9
biorxiv(2023)
Lennart Enders,Marton Siklos, Jan Borggräfe,Stefan Gaussmann,Anna Koren, Monika Malik,Tatjana Tomek,Michael Schuster,Jiří Reiniš,Elisa Hahn,Andrea Rukavina, Andreas Reicher,
Amanda Ng, Fabian Offensperger, Jose A. Cisneros,Natalie S. Scholes, Monika Malik, Ludovica Villanti,Andrea Rukavina,Evandro Ferrada,J. Thomas Hannich,Anna Koren,Stefan Kubicek,Giulio Superti-Furga,
Gang Xue,Jianing Xie, Matthias Hinterndorfer,Marko Cigler, Lara Dötsch,Hana Imrichova,Philipp Lampe, Xiufen Cheng, Soheila Rezaei Adariani,Georg E. Winter,Herbert Waldmann
Nature communicationsno. 1 (2023): 1-13
biorxiv(2023)
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