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A major research focus of our lab was inspired by a remarkably effective but poorly understood therapy for epilepsy: the ketogenic diet. Used mainly for the many patients with drug-resistant epilepsy, this high fat, very low carbohydrate diet produces a dramatic reduction or elimination in seizures for most patients. We are investigating the possible role of metabolically-sensitive K+ channels (KATP channels) in the mechanism of the diet, and learning about their basic role in neuronal firing. We have discovered that a change in fuel supply to brain cells, or in their genetic preference for certain fuels, can produce opening of KATP channels in various central neurons. Opening of these channels slows action potential firing and may contribute to the anticonvulsant mechanism.
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Margarete Diaz-Cuadros,Teemu P Miettinen,Owen S Skinner, Dylan Sheedy,Carlos Manlio Díaz-García, Svetlana Gapon, Alexis Hubaud,Gary Yellen,Scott R Manalis, William M Oldham,Olivier Pourquié
Natureno. 7956 (2023)
biorxiv(2023)
Research squareno. 10 (2023): 1820-1835
Ketogenic Diet and Metabolic Therapiespp.321-335, (2022)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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