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There are three common alleles of APOE: APOE2, APOE3, and APOE4. APOE3 is the most common form; APOE2 (present in about 10% of the US population) lowers the risk of Alzheimer’s disease by 50%; and APOE4 (present in about 25% of the US population) increases the risk by 300%. We are exploring the roles of APOE in the normal regulation of cholesterol metabolism and inflammation in the central nervous system. For this work, we are examining neurons and glia in culture, to look at normal regulation and metabolism of APOE. We are examining the structure of the APOE protein, and its post-translational modifications and association with brain lipoproteins. We are examining mouse models in which the mouse APOE was replaced by the human forms of APOE, studying their sensitivity to brain insults, including exposure to chemotherapeutic agents. Our recent data show that APOE genotype also affects the occurrence of cognitive impairment after chemotherapy, a debilitating side effect of many cancer treatments. Our goals are to understand why APOE affects the risk of Alzheimer’s disease and chemotherapy-induced cognitive impairment so strongly and to define what can be done to lower one’s risk.
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MOLECULAR NEURODEGENERATIONno. 1 (2024)
International Journal of Obesitypp.1-8, (2024)
Frontiers in neuroscience (2023): 1068334
Griffin A Greco, Mitchell Rock, Matthew Amontree,Maria Fe Lanfranco,Holly Korthas, Sung Hyeok Hong,R Scott Turner,G William Rebeck,Katherine Conant
Molecular and cellular neurosciences (2023): 103844-103844
Neurobiology of disease (2022): 105915-105915
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