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The focus of the research of the emeritus group is the functional analysis of electrogenic membrane proteins. Transporters, ion pumps as well as ion channels are under investigation. Electrical, electrophysiological and spectroscopic methods are applied.
The methodological spectrum is completed by protein purification and molecular biology approaches In order to obtain a detailed view of the transport across the membrane. Kinetic methods are applied to study transport and conformational dynamics of the proteins in situ and in vitro. The main topic is the functional and structural analysis of microbial rhodopsins, which can be used as optogenetic tools. The most prominent player within this class of proteins is channelrhodopsin 2 (ChR2). ChR2 was described by us as the first light-gated channel, which became a long-sought tool in neurobiology, because its insertion in electrically excitable cells (neurons, muscle cells) yields the depolarisation and thereby the activation of the cells.
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论文共 145 篇作者统计合作学者相似作者
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Journal of Molecular Biologyno. 5 (2024): 168447-168447
Ana-Sofia Eria-Oliveira,Mathilde Folacci,Anne-Amandine Chassot, Sandrine Fédou, Nadine Thézé,Dmitrii Zabelskii,Alexey Alekseev,Ernst Bamberg,Valentin Gordeliy,Guillaume Sandoz,Michel Vivaudou
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Nikolay S. Ilyinsky, Siarhei Bukhalovich, D. Bagaeva,Semen V. Nesterov,Alexey Alekseev, Fedor M. Tsybrov,Andrey Bogorodskiy, Olga Moiseeva, Anna Vlasova,Kirill Kovalev, А. И. Михайлов,Andrey Rogachev,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Elena Buhl,Tom Resler, Rebecca Lam,Marvin Asido,Ernst Bamberg,Ramona Schlesinger,Christian Bamann,Joachim Heberle,Josef Wachtveitl
Journal of the American Chemical Societyno. 40 (2023): 21832-21840
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Photochemical & Photobiological Sciencesno. 8 (2023): 1809-1823
Communications Chemistryno. 1 (2023): 1-16
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