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The main interest of our lab has been the molecular basis of the regulation of human natural killer (NK) cell function in the context of different stimuli and the contribution of activating and inhibitory receptors to intracellular signals that dictate NK cell reactivity. NK cells are lymphocytes with important functions that include defense against viral and parasitic infections, elimination of tumor cells, regulation of adaptive immunity through cytotoxicity and cytokine secretion, and stimulation of vascular remodeling in early pregnancy. Fundamental knowledge on the regulation of natural killer cells can be applied to study their function in diseases such as cancer and malaria.
Severe malaria caused by Plasmodium falciparum parasite infection kills approximately 280,000 young children every year. Resistance to malaria is dependent on antibodies that are acquired after years of exposure. We have shown that NK cells destroy P. falciparum-infected red blood cells in the presence of antibodies from adults that have acquired clinical immunity to malaria. The antibody-dependent cellular cytotoxicity (ADCC) response of NK cells that we measured in peripheral blood samples obtained from people living in a region of high malaria transmission was associated with greater resistance to disease. A more detailed examination of the composition and function of NK cells in people exposed to intense malaria transmission is needed. See more about the NIAID Malaria Research Program and the MRP Collaborative Research Fellowship Award.
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Cell Reportsno. 4 (2024): 114105-114105
bioRxiv (Cold Spring Harbor Laboratory) (2023)
PLoS pathogensno. 11 (2023): e1011585-e1011585
crossref(2022)
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