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Much of our research focuses on the mosquito vector of dengue virus, Aedes aegypti.
There is growing evidence that mosquitoes vary with respect to their ability to transmit dengue virus and hence play a role in determining the landscape of circulating dengue viruses in the field. We use a combination of vector competence assays, quantitative genetic breeding approaches and genomics to tease apart the relative contributions of the mosquito and viral genomes to transmissibility and their interaction with a range of environmental variables including temperature and microflora. We are also interested in improving the way that we study mosquito transmission, focusing on the key endpoint of mosquito saliva. By studying virus titer and time to infectiousness in the saliva, we are focusing on the most relevant epidemiological measure in the absence of an animal model and but also capturing the full suite of the infection process inside the mosquito. Using these approaches we have demonstrated the heritability of a range of saliva-based measures of vector competence and begun identifying the underlying mosquito genes and pathways involved in their expression. We have also made inroads into understanding viral infection dynamics over the lifetime of the mosquito.
There is growing evidence that mosquitoes vary with respect to their ability to transmit dengue virus and hence play a role in determining the landscape of circulating dengue viruses in the field. We use a combination of vector competence assays, quantitative genetic breeding approaches and genomics to tease apart the relative contributions of the mosquito and viral genomes to transmissibility and their interaction with a range of environmental variables including temperature and microflora. We are also interested in improving the way that we study mosquito transmission, focusing on the key endpoint of mosquito saliva. By studying virus titer and time to infectiousness in the saliva, we are focusing on the most relevant epidemiological measure in the absence of an animal model and but also capturing the full suite of the infection process inside the mosquito. Using these approaches we have demonstrated the heritability of a range of saliva-based measures of vector competence and begun identifying the underlying mosquito genes and pathways involved in their expression. We have also made inroads into understanding viral infection dynamics over the lifetime of the mosquito.
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论文共 123 篇作者统计合作学者相似作者
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INSECT MOLECULAR BIOLOGY (2024)
PLoS biologyno. 3 (2024): e3002573-e3002573
Nina L. Dennington,Marissa K. Grossman, Fhallon Ware-Gilmore, Janet L. Teeple,Leah R. Johnson,Marta S. Shocket,Elizabeth A. McGraw,Matthew B. Thomas
GLOBAL CHANGE BIOLOGYno. 1 (2024): e17041-e17041
PLOS BIOLOGYno. 3 (2024): e3002573-e3002573
Mario L. Novelo, Heverton L. C. F. Dutra,Hillery A. Metz,Matthew Jones,Leah Sigle,Francesca Frentiu,Scott Allen,Stephen Chenoweth,Elizabeth McGraw
PLOS PATHOGENSno. 4 (2023): e1011307-e1011307
Meng-Jia Lau,Heverton Lc Dutra,Matthew Jones, Brianna P. McNulty, Antonio Aja Díaz,Fhallon Ware-Gilmore,Elizabeth A. McGraw
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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