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职业迁徙
个人简介
I am interested in how genes influence metabolism. In dogs, selective breeding has resulted an unusual genetic architecture that makes mapping disease-associated loci remarkably tractable with much smaller numbers than in human populations. We study pet dogs and use comparative genomics to identify genes that are responsible for determining obesity susceptibility in dogs and humans.
The mechanism of action and physiological consequences of variants of interest are tested in the lab in cellular models, and at a whole-dog level by examining their effect on eating behaviour and physiology. All our canine studies are carried out with volunteer owners and their pet or working dogs.
Our overall aim is to understand how genes link to obesity in both dogs and humans, to reveal mechanistic links and identify targets to improve obesity prevention and treatment.
The mechanism of action and physiological consequences of variants of interest are tested in the lab in cellular models, and at a whole-dog level by examining their effect on eating behaviour and physiology. All our canine studies are carried out with volunteer owners and their pet or working dogs.
Our overall aim is to understand how genes link to obesity in both dogs and humans, to reveal mechanistic links and identify targets to improve obesity prevention and treatment.
研究兴趣
论文共 35 篇作者统计合作学者相似作者
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Marie T Dittmann, Gabriella Lakatos, Jodie F Wainwright,Jacek Mokrosinski, Eloise Cross,I Sadaf Farooqi, Natalie J Wallis,Lewis G Halsey,Rory Wilson, Stephen O'Rahilly,Giles S H Yeo,Eleanor Raffan
Science advancesno. 10 (2024): eadj3823-eadj3823
Marie T. Dittmann,Gabriella Lakatos, Jodie F. Wainwright,Jacek Mokrosinski,Eloise Cross,I. Sadaf Farooqi, Natalie J. Wallis,Lewis G. Halsey,Rory Wilson, Stephen O'Rahilly,Giles S. H. Yeo,Eleanor Raffan
SCIENCE ADVANCESno. 10 (2024)
The Veterinary recordno. 6 (2023): e3410-e3410
Endocrine Abstracts (2022)
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Natalie Wallis,Eleanor Raffan
GENESno. 11 (2020): 1378
Journal of Veterinary Internal Medicineno. 1 (2016)
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Eleanor Raffan,Rowena J Dennis,Conor J O'Donovan,Julia M Becker,Robert A Scott,Stephen P Smith, David J Withers, Claire J Wood,Elena Conci,Dylan N Clements,Kim M Summers,Alexander J German,
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