基本信息
浏览量:6
职业迁徙
个人简介
My lab has focused on the regulation of cell signaling in cancer through protein palmitoylation in response to the non-canonical Wnt signaling pathway. The goal has been to develop a biochemically tractable system to begin to understand how non-canonical Wnt signaling regulates cell polarity Treatment of melanoma cells with purified Wnt5a induces a cell polarity phenotype involving the polarized localization of the cell adhesion molecule MCAM. We discovered that MCAM is palmitoylated and Wnt5a activation induces depalmitoylation. When the palmitoylated cysteine residue is mutated to glycine MCAM asymmetrically localizes independent of Wnt5a treatment. This demonstrated a novel pathway originating with Wnt5a binding and resulting in depalmitoylation of MCAM by the enzyme APT1. We have further shown that Wnt5a signaling induces phosphorylation of APT1 on specific serine residues and this modification increases APT1 activity and metastatic behavior of melanoma cells.
研究兴趣
论文共 27 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn