基本信息
浏览量:4
职业迁徙
个人简介
Her current research interests reside on neurodevelopmental alterations and age-related neurodegenerative disorders, namely Alzheimer’s disease (AD) and Amyotrophic Lateral Sclerosis (ALS), with a main focus on neuroinflammatory signaling pathways and dysregulated neuronal-glia cross-talk, including the shedding, microRNA content and distribution of extracellular vesicles (EVs), such as exosomes. In terms of scientific contributions, she helped to define some of the pathways and mechanisms participating in astrocyte aberrancies, in EVs/secretome-mediated microglia activation and in aging-associated alterations in ALS and AD. She recently identified a set of inflammatory-associated miRNAs as determining glia polarization and neurodegeneration. In recent work, the lab has been using astrocytes directly converted or reprogrammed from patient fibroblasts as disease models to explore the role of these cells in neuroinflammation and their regional pathological diversity. Final goal is to identify targets, early disease biomarkers and develop driven medicines. Dora Brites was awarded with the Santa Casa prize in 2015 for developing an autologous exosome-based therapy to deliver neuroprotective cargoes in ALS, and is part of the European Joint Programme for Neurodegenerative Diseases (JPND) for developing improved models for studying AD. Dora Brites has authored more than 100 papers in peer-reviewed journals ans was recently awarded with the Santa Casa prize in ALS. Dora Brites was/is principal investigator of 18 funded projects. She has successfully supervised 10 Post-Doctoral researchers, 16 PhD students and 33 master thesis. Dora Brites is Head of Neuron Glia Biology in Health and Disease at Research Institute for Medicines (iMed.ULisboa), Professor of Histology and Embriology and of Physiopathology of Neuroinflammation, Institutional Coordinator of Ciência Viva no Laboratório, Secretary of the Assembly Table of the Portuguese Biohemical Societry, Member of the Coordinator/Executive Committee of Portuguese Glial Network, Member of the Coordinator Council and Executive Director of Mind-Brain College and Vice-President of the Scientific Council.
研究兴趣
论文共 201 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 5 (2024): 2786
Ermelinda Santos Silva,Susana Rocha, Rita Candeias Ramos, Helena Coutinho,Cristina Catarino,Fernanda Teixeira, Graça Henriques,Ana Isabel Lopes,Alice Santos-Silva,Dora Brites
PEDIATRIC RESEARCHno. 7 (2022): 1856-1864
Cellsno. 21 (2022): 3377-3377
Fabíola de Carvalho Chaves de Siqueira Mendes,Marina Negrão Frota de Almeida,Manoela Falsoni, Marcia Lorena Ferreira Andrade,André Pinheiro Gurgel Felício,Luisa Taynah Vasconcelos Barbosa da Paixão,Fábio Leite do Amaral Júnior,Daniel Clive Anthony,Dora Brites,Cristovam Wanderley Picanço Diniz,Marcia Consentino Kronka Sosthenes
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn