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Research Summary
The research in Sharma lab is focused in two main areas:
Investigating the molecular links between obesity and cancer, emphasizing aspects that have potential clinical significance and development of novel therapeutics. To get to the bottom of obesity-cancer connection, her lab is exploring the genes, molecules, hormones and cellular processes that could cause and promote cancer in obese people. Using various physiologically relevant mouse models and cell lines, their aim is to find molecular targets that can be effectively targeted by small molecule inhibitors as well as bioactive food components. Their overall goal is to understand the molecular networks by which obesity affects carcinogenesis and discover novel agents to effectively disrupt obesity-cancer axis.
Investigating the molecular mechanisms by which breast cancers acquire resistance to endocrine therapy and develop new treatment strategies to overcome this resistance. In this research, they combine molecular and genetic approaches to focus on the crosstalk between growth factor pathways and coregulator proteins. The goal is to understand the mechanistic links, define molecular profiles that can be used to predict development of endocrine resistance and develop targeted therapies.
The research in Sharma lab is focused in two main areas:
Investigating the molecular links between obesity and cancer, emphasizing aspects that have potential clinical significance and development of novel therapeutics. To get to the bottom of obesity-cancer connection, her lab is exploring the genes, molecules, hormones and cellular processes that could cause and promote cancer in obese people. Using various physiologically relevant mouse models and cell lines, their aim is to find molecular targets that can be effectively targeted by small molecule inhibitors as well as bioactive food components. Their overall goal is to understand the molecular networks by which obesity affects carcinogenesis and discover novel agents to effectively disrupt obesity-cancer axis.
Investigating the molecular mechanisms by which breast cancers acquire resistance to endocrine therapy and develop new treatment strategies to overcome this resistance. In this research, they combine molecular and genetic approaches to focus on the crosstalk between growth factor pathways and coregulator proteins. The goal is to understand the mechanistic links, define molecular profiles that can be used to predict development of endocrine resistance and develop targeted therapies.
研究兴趣
论文共 160 篇作者统计合作学者相似作者
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Jennifer Sheng, Amanda Montanari, Jennifer Trost, Mengyang Lu, Justin Mahosky,Sheetal Parida,Amanda Blackford,Dipali Sharma,Marci Laudenslager,Kimberly Gudzune,Janelle Coughlin,Vered Stearns
Cancer Researchno. 9_Supplement (2024): PO4-11
crossref(2023)
Sheetal Parida,Sumit Siddharth, Himavanth R. R. Gatla,Shaoguang Wu,Guannan Wang, Kathleen Gabrielson,Cynthia L. L. Sears,Brian H. H. Ladle,Dipali Sharma
FRONTIERS IN IMMUNOLOGY (2023): 1194931-1194931
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Cancer Researchno. 7_Supplement (2023): 1720-1720
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Cancer Discoveryno. 5 (2023): 1138-1157
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