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个人简介
Areas of research include:
Novel post-transcriptional regulatory mechanisms. Current projects focus on the biogenesis, mechanisms of repression, and biological roles of viral microRNAs during HSV infection.
Herpesvirus DNA replication proteins: Projects include determining the 3-D structures of these proteins (with the Hogle lab), and the roles of poorly understood structural domains, and exploring their interactions with each other, cellular proteins, and nucleic acids via biochemical, mutational, and biophysical approaches, including (with the Loparo and Golan labs) single molecule methods. These studies should permit detailed understanding of these complicated proteins and rational drug design.
Nuclear egress: How do HCMV nucleocapsids move towards and gain access to the inner nuclear membrane, and bud through it? Projects include biochemical and biophysical studies of a viral enzyme that mimics cyclin-dependent kinase and of a nuclear egress complex (in collaboration with the Hogle lab), and molecular genetic and cell biological studies of these proteins' functions in infected cells.
Drug targets and development of new therapies. Aside from studies of established drug targets (herpesvirus DNA polymerases and the HCMV protein kinase), projects include discovering new antiviral drugs that inhibit protein-protein interactions, and finding new drug targets by a combination of "chemical genetic" and molecular genetic approaches.
HSV latency/pathogenesis. HSV forms latent infections that persist for the life of the host. How this occurs is biologically fascinating and clinically important. Projects entail molecular genetic, and PCR-basedmethods to explore viral gene regulation especially how viral and host microRNAs repress viral gene expression, thereby maintaining latency.
研究兴趣
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Virology (2024): 110035-110035
Han Chen,Ming F. Lye,Christoph Gorgulla,Scott B. Ficarro, Gregory D. Cuny,David A. Scott, Fan Wu, Paul W. Rothlauf, Xiaoou Wang,Rosio Fernandez,Jean M. Pesola, Sorin Draga,
PLOS PATHOGENSno. 11 (2023): e1011781-e1011781
Immunotherapy advancesno. 1 (2023)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 45 (2023)
Katherine Kaugars,Joseph Dardick,Anna Paula de Oliveira,Kayla A Weiss,Regy Lukose,John Kim,Lawrence Leung,Saranathan Rajagopalan, Sydney Wolin, Leor Akabas,David M Knipe,Goran Bajic,
Nature microbiologyno. 5 (2021): 682-696
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