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African trypanosomes are parasitic protists which cause sleeping sickness or Human African Trypanosomiasis (HAT) and the livestock disease, nagana. They are masters of antigenic variation and immune evasion in the host bloodstream. One goal is to understand the molecular mechanisms underlying this process. DNA repair is required to replace the active Variant Surface Glycoprotein (VSG) gene with a new VSG and VSG expression is monoallelic (at a telomere) so our work in this area focuses on understanding mechanisms of DNA recombination and monotelomeric gene expression.
We also seek to understand drug action and resistance. We recently identified >50 genes linked to drug action. Suramin uptake was shown to be via receptor (ISG75)-mediated endocytosis while an aquaglyceroporin (AQP2) controls melarsoprol-pentamidine cross-resistance; AQP2 has now also been linked to clinical cases of melarsoprol resistance.
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biorxiv(2024)
PLOS NEGLECTED TROPICAL DISEASESno. 2 (2024): e0012007-e0012007
MSPHEREno. 1 (2024): e0036323-e0036323
Nature Communicationsno. 1 (2023): 1-18
Frontiers in cellular and infection microbiology (2023): 1204707-1204707
biorxiv(2023)
PLoS pathogensno. 7 (2023): e1011530-e1011530
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