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The goal of the Savage Lab is to understand how protein machinery – including both enzymes and compartmentalization - facilitates the biochemistry of the cell. We are particularly interested in photosynthetic CO2 fixation, a complex set of reactions that must occur in the right place and time to capture and convert light into stored chemical energy. Photosynthesis is uniquely important for human society. It catalyzes the assimilation of inorganic carbon into the organic world and is the ultimate source of nearly all nutritional calories on Earth.
We employ several model organisms including various bacterial species, mammalian cells and plant cells. For the past several years, we have focused much of our effort on the bacterial Carbon dioxide Concentrating Mechanism (CCM), a multi-scale, multi-component system that functions to increase the rate and specificity of the critical enzyme ribulose-1,5-bisphosphate carboxylase / oxygenase (Rubisco). We use the tools of biochemistry, molecular biology, and synthetic biology to identify and characterize the key players and mechanistic principles underlying CCM function. Ultimately, we hope to develop a total cell biological understanding of how CCM function emerges from individual components and to use this understanding for the improvement of photosynthetic CO2 fixation in plants.
We are therefore also interested in the development of novel genome editing technologies for accelerating genetic experiments in plants. Given the generality of these tools, we also explore how engineered genome editors can be used to improve editing in human cells. Our specific areas of research are as follows.
The goal of the Savage Lab is to understand how protein machinery – including both enzymes and compartmentalization - facilitates the biochemistry of the cell. We are particularly interested in photosynthetic CO2 fixation, a complex set of reactions that must occur in the right place and time to capture and convert light into stored chemical energy. Photosynthesis is uniquely important for human society. It catalyzes the assimilation of inorganic carbon into the organic world and is the ultimate source of nearly all nutritional calories on Earth.
We employ several model organisms including various bacterial species, mammalian cells and plant cells. For the past several years, we have focused much of our effort on the bacterial Carbon dioxide Concentrating Mechanism (CCM), a multi-scale, multi-component system that functions to increase the rate and specificity of the critical enzyme ribulose-1,5-bisphosphate carboxylase / oxygenase (Rubisco). We use the tools of biochemistry, molecular biology, and synthetic biology to identify and characterize the key players and mechanistic principles underlying CCM function. Ultimately, we hope to develop a total cell biological understanding of how CCM function emerges from individual components and to use this understanding for the improvement of photosynthetic CO2 fixation in plants.
We are therefore also interested in the development of novel genome editing technologies for accelerating genetic experiments in plants. Given the generality of these tools, we also explore how engineered genome editors can be used to improve editing in human cells. Our specific areas of research are as follows.
研究兴趣
论文共 65 篇作者统计合作学者相似作者
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Noam Prywes, Naiya R. Philips,Luke M. Oltrogge, Sebastian Lindner, Yi-Chin Candace Tsai,Benoit de Pins, Aidan E. Cowan,Leah J. Taylor-Kearney, Hana A. Chang, Laina N. Hall, Daniel Bellieny-Rabelo, Hunter M. Nisonoff,
biorxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
arxiv(2023)
Cecilia Blikstad,Eli J. Dugan,Thomas G. Laughlin, Julia B. Turnsek,Mira D. Liu,Sophie R. Shoemaker, Nikoleta Vogiatzi,Jonathan P. Remis,David F. Savage
Cecilia Blikstad,Eli J. Dugan,Thomas G. Laughlin, Julia B. Turnšek,Mira D. Liu,Sophie R. Shoemaker, Nikoleta Vogiatzi,Jonathan P. Remis,David F. Savage
biorxiv(2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 49 (2022): e2210539119-e2210539119
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