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Dr. Theodorescu is known for his work on the molecular mechanisms underlying bladder cancer and tools that determine drug response as well as the discovery of new drugs for cancer. Examples include the discovery of genes that regulate tumor growth and metastasis (RhoGDI2, AGL, GON4L), and novel biomarkers (DNA/NGS, RNA and proteomic) and concepts for precision therapeutic approaches such as the COXEN principle, which is being tested in national (SWOG) clinical trials. He also conceptualized the approach and then led the discovery and development of a "first in class" RalGTPase inhibitor as a new therapeutic in cancer. This drug was awarded a U.S. patent and is in commercial development. His laboratory is funded by grants from the NIH-NCI. Dr. Theodorescu has published over 300 articles including articles in Nature, Science, Cancer Cell, PNAS and JCI.
研究兴趣
论文共 627 篇作者统计合作学者相似作者
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Arsen Osipov, Ognjen Nikolic,Arkadiusz Gertych,Sarah Parker,Andrew Hendifar, Pranav Singh, Darya Filippova,Grant Dagliyan,Cristina R. Ferrone,Lei Zheng,Jason H. Moore,Warren Tourtellotte,
Nature Cancerno. 2 (2024): 299-314
Natureno. 7999 (2024): E11-E11
Lily Elizabeth R. Feldman, Saswat Mohapatra,Robert Jones, Charlene Tilton,Tahlita Zuiverloon,James Costello,Dan Theodorescu
Cancer Researchno. 7_Supplement (2024)
Jason H Moore, Xi Li, Jui-Hsuan Chang, Nicholas P Tatonetti,Dan Theodorescu,Yong Chen,Folkert W Asselbergs, Mythreye Venkatesan,Zhiping Paul Wang
Biocomputing 2024 (2024): 96-107
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Clinical cancer research : an official journal of the American Association for Cancer Researchno. 2 (2024): 444-449
NATURE CANCERno. 2 (2024): 226-227
Nature Reviews Disease Primersno. 1 (2023): 1-21
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