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Nucleic acid chemistry with a focus on chemical modifications to DNA and RNA bases forms the core of our program. In DNA, such modifications are typically deleterious leading to mutations, genetic diseases and cancer; however, altered bases in RNA are of interest to help explain the role of RNA in the origin and evolution of life, specifically primitive metabolic processes on early Earth. These studies also help us understand how to modify nucleic acids to alter the function of DNA or RNA in the cell, or to analyze nucleic acids extracted from cells. Members of the lab include organic, biological, analytical and inorganic chemists.
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论文共 432 篇作者统计合作学者相似作者
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ISRAEL JOURNAL OF CHEMISTRYno. 3-4 (2024)
Alessia Bellina,Matilde Clarissa Malfatti, Gilmar Salgado,Aaron M. Fleming,Giulia Antoniali, Nicolò Gualandi,Sara La Manna,Daniela Marasco,Erik Dassi,Cynthia J. Burrows,Gianluca Tell
biorxiv(2024)
biorxiv(2024)
RSC Chemical Biologyno. 4 (2023): 261-270
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Chemical Communicationsno. 58 (2023): 8997-9000
RSC chemical biologyno. 11 (2023): 952-964
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D-Core
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