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The hematopoietic stem cell is capable of maintaining the output of >10 cellular lineage for the entire lifespan of the organism. This is made possible by the presence of structures (niches) dedicated to long-term maintenance of the multi-potent stem cell state, as well as mechanisms for the generation and subsequent lineage specification of stem cell progeny lacking long-term self-renewal capacity.
We use genetic methods, combined with genome-wide gene expression and chromatin profiling, to address the complexity of the hematopoietic stem cell population, the niches that maintain them, and the changes hematopoietic stem cells and niches undergo during aging. We investigate the regulators (transcription factors, signaling molecules) that control the lineage commitment of multi-potent hematopoietic progenitors, as well as the cellular pathways that they specify. Finally, we model how mutations affecting the normal transcriptional control of myelopoiesis result in acute myeloid leukemia, and address how the leukemic stem cells responsible for the disease are maintained.
We use genetic methods, combined with genome-wide gene expression and chromatin profiling, to address the complexity of the hematopoietic stem cell population, the niches that maintain them, and the changes hematopoietic stem cells and niches undergo during aging. We investigate the regulators (transcription factors, signaling molecules) that control the lineage commitment of multi-potent hematopoietic progenitors, as well as the cellular pathways that they specify. Finally, we model how mutations affecting the normal transcriptional control of myelopoiesis result in acute myeloid leukemia, and address how the leukemic stem cells responsible for the disease are maintained.
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Bloodno. 19 (2023): 1622-1632
Bloodno. Supplement 1 (2023): 34-34
Monika Malik, Fei Guo,Aman Asif-Malik, Vasileios Eftychidis,Nikolaos Barkas, Elena Eliseeva,Kerstin N. Timm, David A. Bergin, Barbara Zonta,Peter J. Magill,Claus Nerlov,Liliana Minichiello
Research Square (Research Square) (2023)
Nature communicationsno. 1 (2023): 6062-18
HemaSphereno. S3 (2023): e8112156-e8112156
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
Nature Cell Biologyno. 6 (2023): 812-822
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