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"Thedeciphering (signaling) of the carbohydrate code in cells will undoubtedly opennew vistas in biology." Stryer's Biochemsitry,4th edition. Chapter18(CARBOHYDRATE), PAGE 479 Functional glycobiology and glycomic studies on human diseases andbiodiversity by supra molecular system and establishment of novel industrialbasisChange of the cell surface glycosylation is one of the most important modifications that occur in cellular transformation such as development, differentiation, growth, aging, immune system and oncogenesis. Membrane domain is a transient supra-molecular organization assembled by specific glycoconjugates and sphingolipids. Although domain formation is promoted by purely physical interactions between components, synthesis and distribution of these components are under strict genetic control. Both glycoproteins and glycolipids carbohydrate moieties are affected by cellular transformation, leading to the appearance of carbohydrate tumor associated antigens (CTAA). These changes in glycosylation have been described for a large number of cancer types and are usually associated with a poor prognosis for the patients. Most of the CTAA are sialylated antigens and the increase of sialylation is a well-known general feature of transformed cells. As an example, the mucin-type Sialyl-Tn antigen is increased in pancreas, gastric, colon, uterus and breast cancers and associated with a poor prognosis for the patients. Modifications of cellular glycosylation are a common phenotypic change in malignancy. However, only a limited number of biosynthetic pathways are frequently altered in cancer.
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Molecular Immunology (2024): 50-57
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASEno. 3 (2024): 167019-167019
XENOTRANSPLANTATIONno. 2 (2024): exen12855-exen12855
International Journal of Molecular Sciencesno. 8226 (2023): 8226-8226
Frontiers in Cellular and Infection Microbiology (2023): 1286423-1286423
PloS oneno. 11 (2023): e0293321-e0293321
Glycoconjugate journalpp.1-10, (2023)
Frontiers in immunology (2023): 1294869
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