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Work is currently underway in Chait’s lab to develop novel spectrometry instrumentation for ultrasensitive, rapid, and comprehensive characterization of proteomes, the entire complement of proteins within cells, at the level of single cells. Existing methods of tandem mass spectrometry involve isolating the ion of interest, fragmenting it, and then measuring the mass spectrum of the fragments. However, much of this process is inherently extremely wasteful, since, at any given time, all ion species except for the one that is specifically isolated are thrown away. The Chait lab is investigating new strategies for overcoming this inefficiency using newly devised instrumentation for carrying out massively parallel mass spectrometry.
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论文共 554 篇作者统计合作学者相似作者
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Thomas C McLean, Francisco Balaguer-Perez,Joshua Chandanani,Christopher M Thomas,Clara Aicart-Ramos, Sophia Burick,Paul Dominic B Olinares, Giulia Gobbato,Julia E A Mundy,Brian T Chait,David M Lawson,Seth A Darst,
biorxiv(2024)
Martin S Taylor,Connie Wu,Peter C Fridy,Stephanie J Zhang,Yasmeen Senussi,Justina C Wolters, Tatiana Cajuso, Wen-Chih Cheng, John D Heaps, Bryant D Miller, Kei Mori,Limor Cohen,
biorxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv : the preprint server for biology (2023)
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Paul Olivier,Fred Mast,Peter Fridy,Natalia Ketaren, Leslie Miller,Tanmoy Sanyal,Michael Rout,Brian Chait,John Aitchison
Journal of Biological Chemistryno. 3 (2023): 104200-S649
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Edmondo Campisi, K. Rashid Rumah,Peter Fridy, Natalia Ketaren,Kelly Molloy,Michael Rout,Brian Chait,Vincent Fischetti
MULTIPLE SCLEROSIS JOURNAL (2023): 239-239
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