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My group's research is focused on attaining a better understanding of the initiation, maintenance, and progression of tumors, and their response to current therapies toward improving future treatment strategies.
My group develops and applies genomic biomarkers of tumor cells, whether detected through biopsy of the primary neoplasm, or noninvasively through monitoring of the bodily fluids including blood. We apply such genomic biomarkers for the early detection, diagnosis, and monitoring of diverse tumors including lymphomas and solid tumors.
We are also interested in better molecular understanding of normal tissue stem cells and their malignant tumor-initiating counterparts (cancer stem cells), toward identification of the underlying mechanisms relevant to specific cancers of the hematopoietic system. These tumors include follicular lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma.
We have also worked to build prognostic and predictive models for clinical and therapeutic outcomes of diverse human malignancies, through large-scale bioinformatic meta-analysis of human tumor transcriptomes, including deconvolution of complex tumor admixtures including infiltrating leukocytes.
In this effort, we help build and employ tools from functional genomics, computational biology, molecular genetics, and mouse models. We are applying this knowledge toward the design of clinical trials in the treatment of patients with various malignancies, whom I care for directly or indirectly, as a clinician specializing in Medical Oncology and Hematology.
My group develops and applies genomic biomarkers of tumor cells, whether detected through biopsy of the primary neoplasm, or noninvasively through monitoring of the bodily fluids including blood. We apply such genomic biomarkers for the early detection, diagnosis, and monitoring of diverse tumors including lymphomas and solid tumors.
We are also interested in better molecular understanding of normal tissue stem cells and their malignant tumor-initiating counterparts (cancer stem cells), toward identification of the underlying mechanisms relevant to specific cancers of the hematopoietic system. These tumors include follicular lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma.
We have also worked to build prognostic and predictive models for clinical and therapeutic outcomes of diverse human malignancies, through large-scale bioinformatic meta-analysis of human tumor transcriptomes, including deconvolution of complex tumor admixtures including infiltrating leukocytes.
In this effort, we help build and employ tools from functional genomics, computational biology, molecular genetics, and mouse models. We are applying this knowledge toward the design of clinical trials in the treatment of patients with various malignancies, whom I care for directly or indirectly, as a clinician specializing in Medical Oncology and Hematology.
研究兴趣
论文共 419 篇作者统计合作学者相似作者
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Cancer Researchno. 6_Supplement (2024): 960-960
William Y. Shi, Kevin J. Liu, Mohammad S. Esfahani,Joseph G. Schroers-Martin,Monica Nesselbush,Simon B. Chen,Stefan K. Alig, Patrick Mullane,Kathleen E. Mach, Ludimila Trabanino,Timothy J. Lee, Ihna Yoo,
Aki Nakao,Aaron M. Newman,Ash A. Alizadeh, Maximilian Diehn, Mistuni Ghosh, Manjula Aliminati, Jayati Ghosh, Kristi Stephenson,Ashutosh Ashutosh
Cancer Researchno. 6_Supplement (2024): 4898-4898
Eliza M. Lauer, Ella Riegler,Jurik A. Mutter,Stefan K. Alig,Sabine Bleul,Julia Kuehn,Lavanya Ranganathan, Christian Klingler,Theo Demerath,Urs Wuertemberger,Alexander Rau,Jakob Weiss,
medrxiv(2024)
Monica C. Nesselbush,Bogdan A. Luca,Young-Jun Jeon, Isabel Jabara, Catherine B. Meador,Michael S. Binkley, Nova Xu,Angela B. Hui,Andrea Garofalo,William Y. Shi,Kevin J. Liu,Takeshi Sugio,
Cancer Researchno. 6_Supplement (2024): 6560-6560
Natureno. 7996 (2024): 778-787
Tanaya Shree,Sarah Haebe,Debra K. Czerwinski, Erik Eckhert,Grady Day,Anuja Sathe, Susan Grimes,Matthew J. Frank,Lauren S. Maeda,Ash A. Alizadeh,Ranjana Advani,Richard T. Hoppe,
Mark P. Hamilton,Takeshi Sugio, Troy Noordenbos, Shuyu Shi,Max Diehn,Dita Gratzinger,David B. Miklos,Ash A. Alizadeh,Zinaida Good
Transplantation and Cellular Therapyno. 2 (2024): S487-S488
Cell stem cellno. 3 (2024): 410-420.e4
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