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职业迁徙
个人简介
The broad theme of the Barron lab is the study and biomimicry of natural host defense peptides (antimicrobial peptides). We study the molecular biophysics and mechanisms of LL-37—a centrally important human host defense peptide—and its involvement in Alzheimer's dementia (via LL-37 dysregulation and degradation by pathogen virulence factors). Alzheimer's dementia can be caused by (or at least, accompanied by) polymicrobial cerebral infections, a phenomenon receiving renewed attention given recent discoveries. We are also working to develop biostable peptoid mimics of LL-37 as therapeutics that can combat antibiotic-resistant infections, especially cerebral infections, ear infections, and sinus / lung infections. Finally, we work to mimic lung surfactant proteins to facilitate delivery of therapeutics to the lungs, treat bacterial and viral pneumonia, or prevent or prevent ventilator-associated lung injury.
We are currently putting efforts into better understanding the pathogenic mechanisms of Covid-19, as relates to dysregulation of innate immunity; understanding why certain minority populations seem to be more strongly affected by Covid-19 infections; and developing safe therapeutic approaches to both preventing and treating severe Covid-19.
We are currently putting efforts into better understanding the pathogenic mechanisms of Covid-19, as relates to dysregulation of innate immunity; understanding why certain minority populations seem to be more strongly affected by Covid-19 infections; and developing safe therapeutic approaches to both preventing and treating severe Covid-19.
研究兴趣
论文共 272 篇作者统计合作学者相似作者
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Wenhan Zhao,Jennifer S. Lin,Josefine Eilso Nielsen, Kristian Sorensen, Anand Sunil Wadurkar,Jingjing Ji,Annelise E. Barron,Shikha Nangia,Matthew R. Libera
ANTIVIRAL RESEARCH (2024): 105821-105821
Qingquan Chen, Pam Cai, Tong Hong Wei Chang,Elizabeth Burgener,Michael J Kratochvil, Aditi Gupta,Aviv Hargil,Patrick R Secor,Josefine Eilso Nielsen,Annelise E Barron,Carlos Milla,Sarah C Heilshorn,
biorxiv(2024)
Contact lens & anterior eye : the journal of the British Contact Lens Associationno. 2 (2024): 102124-102124
Shirin Shamloo,Erwin Defensor, Peter Ciari,Gaku Ogawa, Laura Vidano,Jennifer S. Lin,John A. Fortkort,Mehrdad Shamloo,Annelise E. Barron
Frontiers in Neuroscience (2023): 1150156-1150156
M. Kim, Yeongmi Cheon,Dongmin Shin,Jieun Choi,Josefine Eilsø Nielsen,Myeong Seon Jeong,Ho Yeon Nam,S.E. Kim,Reidar Lund,Håvard Jenssen,Annelise E. Barron, Seongsoo Lee,
Advanced Scienceno. 24 (2023)
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Patrick M Tate,Vincent Mastrodomenico, Christina Cunha, Joshua McClure,Annelise E Barron,Gill Diamond,Bryan C Mounce,Kent Kirshenbaum
ACS infectious diseasesno. 8 (2023): 1508-1522
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Biophysical journal (2023)
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