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His group's work on expression of vaccine antigens in potato led to the first human testing of plant-based vaccines, funded by NIH-NIAID. The first such trial ever conducted showed that volunteers who ate potato tuber expressing E. coli heat-labile enterotoxin B subunit (LTB) developed serum and mucosal antibodies specific for LT-B (Tacket et al., 1998). The next study demonstrated specific antibody responses in humans who ingested potatoes expressing Norwalk virus capsid protein (NVCP) (Tacket et al., 2000). A third trial showed substantial boosting of titers of serum antibodies against hepatitis B surface antigen (HBsAg) in people who were previously vaccinated with the commercial yeast-derived HBsAg vaccine (Thanavala et al., 2005). Although only a few other clinical studies have been published on plant-based vaccines, his lab's work demonstrated the potential for the strategy and spurred other research leading to plant-based verterinary vaccines (Mason et al., 2013).
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Laura C McCoullough, Tomas Sadauskas,Vitina Sozzi, Kai Yan Mak,Hugh Mason,Margaret Littlejohn,Peter A Revill
Journal of virologyno. 4 (2024): e0153823-e0153823
BIOTECHNOLOGY JOURNALno. 1 (2024): e2300319-e2300319
Yianni Droungas,Hugh Mason,Chee Leng Lee,Rachel Hammond,Stephen Locarnini,Renae Walsh,Hans Netter,Peter Revill
Journal of Hepatology (2023): S1028-S1028
Andrew G. Diamos, Mary D. Pardhe,Melissa H. Bergeman,Aigerim S. Kamzina,Michelle P. DiPalma, Sara Aman, Artemio Chaves,Kenneth Lowe,Jacquelyn Kilbourne,Ian B. Hogue,Hugh S. Mason
FRONTIERS IN IMMUNOLOGY (2023): 1085911
VIRUSES-BASELno. 12 (2023): 2348
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