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Blood vessels are a prerequisite for the maintenance of all organ functions. Embryogenesis is dependent on the development and outgrowth of blood vessels, which provide the organism with oxygen and nutrients. Sprouting angiogenesis occurs rarely in the adult organism but can be observed for example during wound healing and also in cancer. Thus, a detailed knowledge about factors regulating angiogenesis and genetic networks, which provide a functional quiescent vascular bed, is highly desirable.
Besides the formation of new blood vessels, maintenance of existing blood vessels is essential as well. Endothelial cells provide the inner lining of all blood vessels. Disturbed endothelial cell functions are implicated in the pathogenesis of several cardiovascular diseases. Our research work aims at identifying critical molecular and cellular mechanisms of cardiovascular diseases and tumor progression. These findings will help to lay the foundation for the development of innovative pharmacological strategies
Our research group is towards this end
examining the signaling interplay between endothelial cells, as well as interactions of endothelial cells with pericytes and tumor cells.
investigate the role of Delta-Notch signaling and other genes, which are implicated in the formation of vascular malformations and vascular tumors.
studying novel factors necessary for barrier functions of blood vessels, and how these control the passage of tumor cells and fluids through the vessel wall. An important research approach deals with the question how genetic alterations in the endothelium affect metabolism.
Besides the formation of new blood vessels, maintenance of existing blood vessels is essential as well. Endothelial cells provide the inner lining of all blood vessels. Disturbed endothelial cell functions are implicated in the pathogenesis of several cardiovascular diseases. Our research work aims at identifying critical molecular and cellular mechanisms of cardiovascular diseases and tumor progression. These findings will help to lay the foundation for the development of innovative pharmacological strategies
Our research group is towards this end
examining the signaling interplay between endothelial cells, as well as interactions of endothelial cells with pericytes and tumor cells.
investigate the role of Delta-Notch signaling and other genes, which are implicated in the formation of vascular malformations and vascular tumors.
studying novel factors necessary for barrier functions of blood vessels, and how these control the passage of tumor cells and fluids through the vessel wall. An important research approach deals with the question how genetic alterations in the endothelium affect metabolism.
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Nature cancerno. 11 (2023): 1544-+
Elisenda Alsina-Sanchis,Ronja Mülfarth,Iris Moll, Sarah Böhn,Lena Wiedmann, Lorea Jordana-Urriza, Tara Ziegelbauer, Eleni Zimmer,Jacqueline Taylor,Francesca De Angelis Rigotti, Adrian Stögbauer,Benedetto Daniele Giaimo,
crossref(2023)
Aijun Li,Simone Muenst, Julius Hoffman, Laurent Starck,Melika Sarem,Andreas Fischer,Gregor Hutter,V. Prasad Shastri
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