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The survival of our most active tissues, such as the brain and heart, throughout decades of a human lifespan presents an extraordinary biological challenge. Mitochondria are central to the life and death of these tissues. While providing the high amount of energy required by these cells and buffering cytoplasmic calcium flux, they also produce many of the molecules that cause cellular damage and house a lethal arsenal of apoptotic cell death machinery. Thus, these organelles require extensive maintenance and quality control processes. Failure in mitochondrial homeostasis is strongly linked to age-related conditions such as neurodegeneration.
To perform the myriad essential cellular roles in complex cells such as neurons mitochondria must be extremely dynamic. They are transported large distances to respond to localised demands for energy and calcium buffering, and undergo frequent fission and fusion events with each other and other organelles.
To perform the myriad essential cellular roles in complex cells such as neurons mitochondria must be extremely dynamic. They are transported large distances to respond to localised demands for energy and calcium buffering, and undergo frequent fission and fusion events with each other and other organelles.
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Molecular Neurodegenerationno. 1 (2024): 1-21
Madeleine J. Twyning,Roberta Tufi, Thomas P. Gleeson, Kinga M. Kolodziej,Susanna Campesan,Ana Terriente-Felix, Lewis Collins,Federica De Lazzari,Flaviano Giorgini,Alexander J. Whitworth
CELL REPORTSno. 2 (2024): 113681-113681
Deepthy Francis, Francesco Paonessa, Caroline C.G. Fabre,Victoria L. Hewitt, Maria E. Giannakou, Isabel Peset,Alexander J Whitworth, Rick Livesey,Isabel M Palacios
crossref(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
biorxiv(2023)
Wing Hei Au,Leonor Miller-Fleming,Alvaro Sanchez-Martinez, James A. K. Lee,Madeleine J. Twyning,Hiran A. Prag, Sarah Granger, Katie Roome,Laura Ferraiuolo,Heather Mortiboys,Alexander J. Whitworth
biorxiv(2023)
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