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个人简介
A translational biologist and laboratory researcher, Ashworth's research focuses on understanding breast cancer genetics to improve the treatment and care of patients. He was a key part of the team that identified the BRCA2 breast cancer susceptibility gene that is linked to an increased risk for some types of cancer. Ten years later, he discovered how to kill BRCA1- and 2-related tumor cells by treating them with PARP inhibitors which are drugs that increase the damage caused by the broken DNA repair machinery in those cells. This exemplifies the principle of synthetic lethality as cancer therapy. Three different PARP inhibitors are now approved by the FDA.
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论文共 703 篇作者统计合作学者相似作者
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Lei Lu, Xuxu Gou,Sophia K Tan,Samuel I Mann,Hyunjun Yang,Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo,Hyunil Jo,Yibing Wu,Morgan E Diolaiti,Alan Ashworth,
Science (New York, N.Y.)no. 6691 (2024): 106-112
Zhiping Li,Xuanmao Jiao, Taimoor Khan, Danni Li,Shan Zha,Lai Yee Phoon,Li Lan,A. Gordon Robertson,Anthony W. Ashton, Kenneth A. Iczkowski, Alexander D. Borowsky,Alan Ashworth,
Cancer Researchno. 6_Supplement (2024): 5581-5581
Shan Gao,Ilirjana Bajrami,Clare Verrill, Asha Kigozi,Djamila Ouaret,Tamara Aleksic,Ruth Asher,Cheng Han,Paul Allen, Deborah Bailey, Stephan Feller, Takeshi Kashima,
crossref(2023)
Patrick C. O'Leary,Huadong Chen, Yagmur U. Doruk, Tess Williamson,Benjamin Polacco, Andrew S. McNeal, Tanushree Shenoy,Nupura Kale,Julia Carnevale,Erica Stevenson,David A. Quigley,Jonathan Chou,
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Jonathan Chou,Emily A. Egusa,Sinan Wang,Michelle L. Badura,Fei Lee,Anil P. Bidkar, Jun Zhu, Tanushree Shenoy,Kai Trepka,Troy M. Robinson,Veronica Steri,Jiaoti Huang,
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Ilirjana Bajrami,Jessica R. Frankum,Asha Konde,Rowan E. Miller, Farah L. Rehman,Rachel Brough,James Campbell,David Sims,Rumana Rafiq, Sean Hooper,Lina Chen,Iwanka Kozarewa,
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Ilirjana Bajrami,Jessica R. Frankum,Asha Konde,Rowan E. Miller, Farah L. Rehman,Rachel Brough,James Campbell,David Sims,Rumana Rafiq, Sean Hooper,Lina Chen,Iwanka Kozarewa,
crossref(2023)
medRxiv : the preprint server for health sciencesno. 7 (2023)
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