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个人简介
Alain Fischer's work has been focused for years on immunodeficiency acquired from birth (such as bubble babies) and curative approaches using gene therapies. With Marina Cavazzana-Calvo and Salima Hacein-Bey, he obtained in 1999, the first clinical successes in the world of gene therapies for about ten bubble children, two of whom unfortunately developed leukaemias after a few months, one of whom had died. The test was stopped urgently in 2002. Research will show that these leukaemias are due to random insertion into a proto-oncogene of the drug gene. The trial is restarted in 2004, according to a modified protocol using better retroviral vectors, and will be stopped again in 2005 due to new complications. However, of the 16 children treated to date, 15 are satisfactorily cured of their acute immune deficiency.
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Simon Cauchemez,Giulio Cossu,Giulio Cossu,Giulio Cossu, Nathalie Delzenne, Eran Elinav, Eran Elinav, Didier Fassin,Alain Fischer,Alain Fischer,Alain Fischer,Alain Fischer,
Frontiers in Science (2024)
Claire Soudais, Romane Schaus, Camille Bachelet,Norbert Minet, Sara Mouasni, Cécile Garcin, Caique Lopes Souza, Pierre David, Clara Cousu,Hélène Asnagli,Andrew Parker, Paul Palmquist-Gomes,
Nature Communicationsno. 1 (2024): 1-19
Laure Delage,Francesco Carbone,Quentin Riller,Jean-Luc Zachayus, Erwan Kerbellec,Armelle Buzy,Marie-Claude Stolzenberg,Marine Luka,Camille de Cevins,Georges Kalouche,Remi Favier, Alizee Michel,
La Revue du praticienno. 3 (2023): 247-248
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Quentin Riller,Jacques Fourgeaud,Julie Bruneau,Suk See De Ravin,Grace Smith,Mathieu Fusaro, Samy Meriem,Aude Magerus,Marine Luka, Ghaith Abdessalem,Ludovic Lhermitte,Anne Jamet,
Clinical hematology internationalno. 4 (2023): 87882
Journal of Allergy and Clinical Immunologyno. 5 (2023): 1255-1256
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