A Standard Gamble Study to Determine Health State Utilities Associated with Seizures in Glioma in the UK

Tomos Robinson,Matthew Breckons, Helen Bulbeck,Michael D. Jenkinson,Robin Grant,Luke Vale

Health and Quality of Life Outcomes（2025）

Newcastle University | Brainstrust-The Brain Cancer People | University of Liverpool | University of Edinburgh | London School of Hygiene & Tropical Medicine

Cited 0|Views1

Abstract

Glioma are infiltrative primary brain tumours, which despite treatment, lead to a substantial reduction in life expectancy. Seizures are a common symptom of glioma, and have a serious impact on patient health related quality of life (HRQoL). The study aimed to estimate health state utility values for different types of seizures related to glioma, a serious type of brain tumour. Vignettes for the different health states were initially developed from the existing literature. The health states were then refined in collaboration with patients with previous experience of seizures and clinicians experienced in treating patients with seizures. The final vignettes represented three types of acute seizure: focal aware, focal impaired awareness and tonic clonic and several different health states which combined these acute seizures with other aspects of HRQoL. These vignettes were evaluated by a sample of the UK general public using an online survey and analysed descriptively using the mean and standard deviation. 302 participants, representative of the UK general population in terms of age, sex and geographical region, were included in the estimation sample. For the health states representing acute seizures, the focal aware seizure had the highest mean utility value (0.607), followed by the impaired awareness seizure (0.593) and the tonic clonic seizure (0.522). For the health states that also incorporated wider aspects of HRQoL, the health state utility values ranged from 0.504 (one focal aware seizure per year) to 0.337 (at least one focal impaired awareness seizure per week). Seizures may have a major impact of the HRQoL of patients with glioma. The utility values obtained in the study may be used in future economic evaluations of interventions related to glioma where seizures are either a primary clinical outcome or an adverse event.

Translated text

Bibtex

AI Read Science

AI Summary

AI Summary is the key point extracted automatically understanding the full text of the paper, including the background, methods, results, conclusions, icons and other key content, so that you can get the outline of the paper at a glance.

Example

Background

Key content

Introduction

Methods

Results

Related work

Fund

Key content

Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance

Try using models to generate summary,it takes about 60s

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Data Disclaimer

The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn

Chat Paper

【要点】：本研究旨在估算与胶质瘤相关的不同类型癫痫发作的健康状态效用值，以评估其对患者生活质量的影响。

【方法】：通过文献回顾开发健康状态情景，与有癫痫经验的病人和有治疗癫痫病人经验的医生合作完善这些情景，并使用标准博弈法结合在线调查获取英国公众的健康状态效用值。

【实验】：研究采用了302名代表性样本，通过在线调查评估了三种急性癫痫发作（灶性意识清晰、灶性意识障碍和强直阵挛）与不同生活质量方面的健康状态效用值，结果显示灶性意识清晰癫痫的健康效用值最高（0.607），灶性意识障碍癫痫次之（0.593），强直阵挛癫痫最低（0.522）。同时，结合更广泛的生活质量方面的健康状态效用值在0.504（每年一次灶性意识清晰癫痫）到0.337（每周至少一次灶性意识障碍癫痫）之间。数据集名称未在文本中明确提及。

去 AI 文献库对话