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    • Sustained Effects of Capsaicin Infusion into the Oropharynx on Swallowing in Perfused Rats

    LARYNGOSCOPE（2024）

    Department of Otolaryngology-Head and Neck Surgery | Int Univ Hlth & Welf | Univ Melbourne

    Cited 1|Views12
    Abstract
    Objectives To examine the sustained effects of oropharyngeal capsaicin stimulation on the regulation of swallowing, we recorded the swallowing‐related nerve activities during continuous infusion of capsaicin solution into the oropharynx. Methods In 33 in situ perfused brainstem preparation of rats, we recorded the activities of the vagus, hypoglossal, and phrenic nerves during fictive swallowing. The interburst intervals (IBIs) of the swallowing‐related nerves during sequential pharyngeal swallowing (sPSW) elicited by electrical stimulation of the superior laryngeal nerve (SLN) during concurrent capsaicin stimulation of 10, 1, and 0.1 μM ( n = 28) were compared with those during oropharyngeal infusion of saline (control) ( n = 5). Results The IBIs during SLN‐induced sPSW were reduced at 5 min after initiation of continuous infusion of 10 and 1 μM capsaicin solution. The IBIs showed significant decreases to −25.8 ± 6.9%, −25.9 ± 5.3, −18.3 ± 3.7, and −12.0 ± 1.6 at 30 min following 1 μM capsaicin stimulation at SLN stimulus conditions at 5 Hz of 1.2 times threshold, 10 Hz of 40 μA, 5 Hz of 60 μA, and 10 Hz of 60 μA, respectively. Continuous capsaicin stimulation of 0.1 μM solution did not show significant sustained effects. Conclusion Pharmacological stimulation of capsaicin could provide time‐dependent effects on the likelihood of swallowing, particularly subserving sustained facilitation of swallowing reflex with appropriate concentration of capsaicin. Level of Evidence NA Laryngoscope , 134:305–314, 2024
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    capsaicin,perfused brainstem preparation,rats,swallowing
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    【要点】：本研究探讨了持续给予咽部辣椒素对大鼠吞咽神经活动的影响，发现适当浓度的辣椒素能显著促进吞咽反射。
    

    【方法】：在33只大鼠脑干原位灌注模型中，记录了在持续咽部辣椒素溶液灌注过程中，迷走神经、舌下神经和膈神经的吞咽相关活动。
    

    【实验】：通过电刺激喉上神经（SLN）诱发连续咽部吞咽，并比较了10、1和0.1 μM辣椒素溶液（n=28）与生理盐水对照组（n=5）下的吞咽神经活动间隔（IBIs）。结果显示，在10和1 μM辣椒素溶液连续灌注5分钟后，SLN诱发的吞咽活动间隔缩短；30分钟后，1 μM辣椒素刺激下的吞咽活动间隔显著降低。而0.1 μM辣椒素溶液的持续刺激未表现出显著的持续效果。