Elevated Levels of PAI-1 Precede the Occurrence of Type 2 Diabetes Mellitus

Jenny Hernestål-Boman, Tina Öhman, Jan-Håkan Jansson,Marcus M. Lind,Olov Rolandsson,Ingvar A. Bergdahl,Lars Johansson

Diabetology & Metabolic Syndrome（2025）

University Hospital of Umeå | Umeå University

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Abstract

Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of the fibrinolytic system and is mainly secreted from adipose tissue. It is associated with cardiovascular disease and has also been considered a possible early risk marker for type 2 diabetes. Here, we present the results of a large prospective study investigating PAI-1 levels in relation to incident type 2 diabetes mellitus. We conducted a prospective incident case-referent study within the Västerbotten Intervention Programme (VIP). Data on cardiovascular risk factors, fasting plasma glucose (FPG) and 2-hour plasma glucose (2-hPG) were collected at baseline health examination 1990–2005. Blood samples were collected and stored for future analyses. Participants were followed and 484 cases developed type 2 diabetes. Referents without type 2 diabetes were matched for sex, age, and year of participation, n = 484. Baseline plasma samples were analysed for PAI-1. Subgroup analysis was performed for 201 cases and 201 matched referents with normal baseline glucose levels (FPG < 6.1 and 2hPG < 8.9 mmol/L). Elevated baseline levels of PAI-1 were associated with incident type 2 diabetes after adjustments for BMI, family history of diabetes, smoking status, hypertension, FPG and 2hPG (PAI-1; OR = 1.87, 95

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Key words

Type 2 diabetes,Plasminogen activator inhibitor-1,Population study,Västerbotten intervention programme

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【要点】：研究发现PAI-1水平升高是2型糖尿病发生的早期风险标志。

【方法】：通过在Västerbotten干预计划（VIP）中进行的前瞻性病例-参照研究，分析PAI-1水平与2型糖尿病发病风险的关系。

【实验】：在1990-2005年期间，对参与者的心血管风险因素、空腹血糖（FPG）和餐后2小时血糖（2-hPG）进行基线检测，收集血液样本并在之后进行分析，共跟踪到484例2型糖尿病病例，并与相同数量无糖尿病的参照者进行匹配分析。在正常血糖水平的子组分析中，发现基线PAI-1水平升高与2型糖尿病的发生有显著相关性。

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