Deeper Analysis to Identify the True Benefit of ICIs Immunotherapy in First-Line Treatment for Non-HER2-Positive/HER2-Negative Advanced or Metastatic Advanced or Metastatic Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJC)

Bowen Zheng, Fanzhuoran Lou, Yuting He, Miao Fu, Xintian Huang, Weijuan Tan,Quan Chen, Xiaowen Xie,Tianhui Hu,Li Xiao

Cancers（2025）

National Institute for Data Science in Health and Medicine

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Abstract

Gastric cancer (GC) has a high global incidence and mortality rate [...]

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Key words

gastric cancer,gastroesophageal junction cancer,immune checkpoint inhibitors,positive programmed death ligand 1

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Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance

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【要点】：本文通过深入分析，确定了免疫检查点抑制剂（ICIs）在一线治疗非HER2阳性/HER2阴性晚期或转移性胃癌（GC）或胃食管交界癌（GEJC）中的真正益处。

【方法】：研究采用回顾性数据分析和元回归分析，对比了接受ICIs治疗和未接受ICIs治疗的患者的总生存期（OS）和无病生存期（DFS）。

【实验】：通过分析来自多个临床试验的数据，包括KEYNOTE-061、ATTRACTION-2、以及CheckMate-548等，发现ICIs治疗能显著提高特定亚组患者的生存期。