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Novel Antimalarial 3-Substituted Quinolones Isosteres with Improved Pharmacokinetic Properties

Siyuan Ge,Rongchao Jian, Qiwei Xuan, Yingxiang Zhu,Xiaofei Ren, Wenjiao Li,Xiaole Chen, Rui-Kang Huang, Chi-Sing Lee,Suet C. Leung,Nicoletta Basilico,Silvia Parapini,Donatella Taramelli,Nattapon Pinthong,Svetlana Antonyuk,Paul M. O'Neill,Zhaojun Sheng,W. David Hong

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（2025）

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关键词
Antimalarial,Plasmodium falciparum,Quinolone,Bioisosteres,Solubility
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