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    • Figure 4 from Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine

    crossref（2024）

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    Abstract
    Profiling of BM-derived CD8+ T cells of patients with HR-MDS and secondary AML with scRNA-seq. A, UMAP of CD8+ T cells identified 11 clusters. A total of 28,449 CD8+ T cells were pooled from four patients with HR-MDS (15,597 cells) and five patients with secondary AML (12,852 cells). B, Bubble plot depicting the average expression of genes used to characterize the clusters. C, Expression of selected genes projected onto UMAPs. D, Heatmap showing selected top DEGs for each cell cluster. E, Ridgeline plots displaying the cytotoxic signature score for each cell cluster, as defined by the expression of key-related genes. F, Ridgeline plots displaying the cell-cycle signature score for each cell cluster.
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
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    【要点】：该论文通过单细胞分析骨髓来源的CD8+ T细胞，揭示了与髓系肿瘤进展和治疗反应相关的通路，发现使用阿扎胞苷治疗后细胞周期和细胞毒性特征的变化。
    

    【方法】：采用单细胞RNA测序技术（scRNA-seq）对高风险骨髓增生异常综合征（HR-MDS）和继发性急性髓系白血病（secondary AML）患者的骨髓CD8+ T细胞进行分类和特征分析。
    

    【实验】：从四位HR-MDS患者和五位继发性AML患者中收集了28,449个CD8+ T细胞，通过UMAP方法将其分为11个簇，分析了各簇中基因表达的平均水平、选定基因的表达情况以及差异表达基因（DEGs），并计算了各簇的细胞毒性特征分数和细胞周期特征分数。