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Enantiomeric C-6 Fluorinated Swainsonine Derivatives As Highly Selective and Potent Inhibitors of Α-Mannosidase and Α-L-rhamnosidase: Design, Synthesis and Structure-Activity Relationship Study

Feng-Teng Gao, Ming Zhang, Yuna Shimadate, Atsushi Kato,Yi-Xian Li,Yue-Mei Jia,Chu-Yi Yu

European Journal of Medicinal Chemistry(2025)

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Key words
Iminosugar,Swainsonine,Fluorination,α-mannosidase and α-l-rhamnosidase inhibition,Structure-activity relationship,Molecular docking
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